BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 1, Issue 2 , Pages 122-127 , April 2008

Significant analgesic effects of one session of postoperative left prefrontal cortex repetitive transcranial magnetic stimulation: A replication study

  • Jeffrey J. Borckardt, PhD

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, SC
    • Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina (MUSC), Charleston, SC
    • Corresponding Author InformationAddress reprint requests to: Dr. Jeffrey J. Borckardt, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St, 518-North, IOP, Charleston, SC 29425.
    • ,
  • Scott T. Reeves, MD

      Affiliations

    • Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina (MUSC), Charleston, SC
    • ,
  • Mitchel Weinstein, MD

      Affiliations

    • Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina (MUSC), Charleston, SC
    • ,
  • Arthur R. Smith, MD

      Affiliations

    • Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina (MUSC), Charleston, SC
    • ,
  • Neal Shelley, BS

      Affiliations

    • Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina (MUSC), Charleston, SC
    • ,
  • F. Andrew Kozel, MD

      Affiliations

    • Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX
    • ,
  • Ziad Nahas, MD

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, SC
    • ,
  • Karl T. Byrne, MD

      Affiliations

    • Department of Surgery, Medical University of South Carolina (MUSC), Charleston, SC
    • ,
  • Katherine Morgan, MD

      Affiliations

    • Department of Surgery, Medical University of South Carolina (MUSC), Charleston, SC
    • ,
  • Mark S. George, MD

      Affiliations

    • Departments of Psychiatry, Radiology, and Neuroscience, Medical University of South Carolina (MUSC), Charleston, SC

Received 25 January 2008 ,Revised 10 April 2008 ,Accepted 14 April 2008.

References 

  1. Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain. 2003;126:1079–1091
  2. Apkarian AV, Sosa Y, Sonty S, Levy RM, Harden RN, Parrish TB, et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci. 2004;24(46):10410–10415
  3. Hadjipavlou G, Dunckley P, Behrens TE, Tracey I. Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: a diffusion tensor imaging study in healthy controls. Pain. 2006;123(1-2):169–178
  4. Reid P, Pridmore S. Improvement in chronic pain with transcranial magnetic stimulation. Aust N Z J Psychiatry. 2001;35(2):252
  5. Graff-Guerrero A, Gonzalez-Olvera J, Fresan A, Gomez-Martin D, Mendez-Nunez JC, Pellicer F. Repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex increases tolerance to human experimental pain. Brain Res Cogn Brain Res. 2005;25(1):153–160
  6. Sampson SM, Rome JD, Rummans TA. Slow-frequency rTMS reduces fibromyalgia pain. Pain Med. 2005;7(2):115–118
  7. Avery DH, Holtzheimer PE, Fawaz W, Russo J, Neumaier J, Dunner DL, et al. Transcranial magnetic stimulation reduces pain in patients with major depression: a sham-controlled study. J Nerv Ment Dis. 2007;195(5):378–381
  8. Lefaucheur JP. New insights into the therapeutic potential of non-invasive transcranial cortical stimulation in chronic neuropathic pain. Pain. 2006;122:11–13
  9. Lefaucheur JP, Drouot X, Menard-Lefaucheur I, Nguyen JP. Neuropathic pain controlled for more than a year by monthly sessions of repetitive transcranial magnetic cortical stimulation. Neurophysiol Clin. 2004;34:91–95
  10. Borckardt JJ, Weinstein M, Reeves ST, Kozel FA, Nahas Z, Smith AR, et al. Post-operative left prefrontal repetitive transcranial magnetic stimulation reduces patient-controlled analgesia use. Anesthesiology. 2006;105(3):1–6
  11. Borckardt JJ, Nahas Z, Koola J, George MS. Estimating resting motor thresholds in tms research and practice: a computer simulation evaluation of best methods. J ECT. 2006;22(3):169–175
  12. Singer JD. Using SAS PROC MIXED to fit multilevel models, hierarchical models and individual growth curves. J Educ Behav Stat. 1998;24(4):323–355
  13. Li X, Nahas Z, Kozel FA, Anderson B, Bohning DE, George MS. Acute left prefrontal transcranial magnetic stimulation in depressed patients is associated with immediately increased activity in prefrontal cortical as well as subcortical regions. Biol Psychiatry. 2004;55(9):882–890
  14. Zubieta JK, Bueller JA, Jackson LR, Scott DJ, Xu Y, Koeppe RA, et al. Placebo effects mediated by endogenous opioid activity on μ-opioid receptors. J Neurosci. 2005;25(34):7754–7762
  15. Gracely RH, Geisser ME, Giesecke T, Grant MAB, Petzke F, Williams DA, et al. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain. 2004;127:835–843
  16. Garcia-Larrea L, Peyron R. Motor cortex stimulation for neuropathic paub:from phenomenology to mechanisms. Neuroimage. 2007;37:S71–S79
  17. Borckardt JJ, Smith AR, Hutcheson K, Johnson K, Nahas Z, Anderson B, et al. Reducing pain and unpleasantness during repetitive transcranial magnetic stimulation. J ECT. 2006;22(4):259–264

 The work was supported by funding from the National Institute for Neurological Disorders and Stroke at the National Institutes of Health (NIH), Cyberonics Inc, and the Neurosciences Institute at MUSC (JJB); the National Institute for Mental Health, NIDA, and NIAAA at NIH, Jazz Pharmaceuticals, GlaxoSmithKline, and Cyberonics Inc (MSG); the National Institute for Mental Health at NIH, and Cyberonics In (ZN); and the National Institute for Mental Health at NIH and the US Department of Defense (AK).

 MUSC has filed 6 patents or invention disclosures in one or more of the authors' names regarding brain imaging and stimulation.

 Dr. George is a consultant for Aspect Biomedical, Argolyn, Aventis, Abbott, Bristol-Meyers Squibb, Cephos, Cyberonics, and Neuropace; however, he has no equity ownership in any device or pharmaceutical company.

 Dr. Nahas is a consultant for Neuropace.

 The views expressed herein are those of the authors and do not necessarily reflect the views of the National Institutes of Health or the US Department of Defense.

PII: S1935-861X(08)00013-2

doi: 10.1016/j.brs.2008.04.002

BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 1, Issue 2 , Pages 122-127 , April 2008

Article Tools

* Image Usage & Resolution