BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 2, Issue 2 , Pages 88-92 , April 2009

Decreasing procedural pain over time of left prefrontal rtms for depression: Initial results from the open-label phase of a multisite trial (OPT-TMS)

  • Berry S. Anderson, PhD(c), RN

      Affiliations

    • Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina
    • Corresponding Author InformationCorrespondence: Mr. Berry S. Anderson, 502 N, Institute of Psychiatry, 67 President St, Charleston, SC, 29425.
    • ,
  • Katie Kavanagh

      Affiliations

    • Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Jeffrey J. Borckardt, PhD

      Affiliations

    • Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Ziad H. Nahas, MD

      Affiliations

    • Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Samet Kose, MD

      Affiliations

    • Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Sarah H. Lisanby, MD

      Affiliations

    • Brain Stimulation and Therapeutic Neuromodulation, New York State Psychiatric Institute, and Columbia University, New York, New York
    • ,
  • William M. McDonald, MD

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • David Avery, MD

      Affiliations

    • Psychiatry Department, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Harold A. Sackeim, PhD

      Affiliations

    • Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York
    • ,
  • Mark S. George, MD

      Affiliations

    • Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina

Received 23 January 2008 ,Revised 11 August 2008 ,Accepted 2 September 2008.

References 

  1. Borckardt JJ, Smith AR, Hutcheson K, et al. Reducing pain and unpleasantness during repetitive transcranial magnetic stimulation. J ECT. 2006;22(4):259–264
  2. O'Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry. 2007;62(11):1208–1216
  3. Fox P, Ingham R, George MS, et al. Imaging human intra-cerebral connectivity by PET during TMS. Neuroreport. 1997;8(12):2787–2791
  4. George MS, Wassermann EM, Williams WA, et al. Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation (rTMS) of the prefrontal cortex. J Neuropsychiatry Clin Neurosci. 1996;8(2):172–180
  5. Pazzaglia PJ, George MS, Post RM, Rubinow DR, Davis CL. Nimodipine increases CSF somatostatin in affectively ill patients. Neuropsychopharmacol. 1995;13(1):75–83
  6. Herwig U, Padberg F, Unger J, Spitzer M, Schonfeldt-Lecuona C. Transcranial magnetic stimulation in therapy studies: examination of the reliability of “standard” coil positioning by neuronavigation. Biol Psychiatry. 2001;50(1):58–61
  7. Johnson KA, Ramsey D, Kozel FA, et al. Using imaging to target the prefrontal cortex for TMS studies in treatment resistant depression. Dialogues in Clin Neurosci. 2006;8(2):266–268
  8. Singer JD. Using Sas PROC MIXED to fit multilevel models, hierarchical models, and individual growth models. J Educational Behavioral Stat. 1998;24(4):323–355
  9. Avery DH, Holtzheimer PE, Fawaz W, et al. Transcranial magnetic stimulation reduces pain in patients with major depression: a sham-controlled study. J Nerv Ment Dis. 2007;195(5):378–381
  10. Borckardt JJ, Weinstein M, Reeves ST, et al. Postoperative left prefrontal repetitive transcranial magnetic stimulation (rTMS) reduces patient-controlled analgesia use. Anesthesiology. 2006;105:557–562

 The study was funded by National Institute of Mental Health (NIMH) Grants R01MH069887, R01MH069896, R01MH069895, R01MH069886, and R01MH069929; and equipment support was provided by Neuronetics, Inc. Additional support for the MUSC Brain Stimulation Laboratory comes from the Stanley Foundation, the National Alliance for Research on Schizophrenia and Depression (NARSAD), NIMH Grant K08MH070615 (Dr Nahas), and NINDS Grant K23NS050485 (Dr Borckardt).

 Conflicts of Interest: MUSC holds several TMS-related patents. Drs George and Sackeim are advisory board members for Neuronetics, Inc.

PII: S1935-861X(08)00333-1

doi: 10.1016/j.brs.2008.09.001

BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 2, Issue 2 , Pages 88-92 , April 2009

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