BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 3, Issue 3 , Pages 131-139 , July 2010

Cortisol-induced effects on human cortical excitability

  • Paolo Milani

      Affiliations

    • Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche e del Comportamento, Universita' di Siena, Siena, Italy
    • ,
  • Pietro Piu

      Affiliations

    • Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche e del Comportamento, Universita' di Siena, Siena, Italy
    • ,
  • Traian Popa

      Affiliations

    • Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche e del Comportamento, Universita' di Siena, Siena, Italy
    • ,
  • Raimondo della Volpe

      Affiliations

    • Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche e del Comportamento, Universita' di Siena, Siena, Italy
    • ,
  • Marco Bonifazi

      Affiliations

    • Dipartimento di Fisiologia, Universita' di Siena, Siena, Italy
    • ,
  • Alessandro Rossi

      Affiliations

    • Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche e del Comportamento, Universita' di Siena, Siena, Italy
    • ,
  • Riccardo Mazzocchio

      Affiliations

    • Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche e del Comportamento, Universita' di Siena, Siena, Italy
    • Corresponding Author InformationCorrespondence: Dr. R. Mazzocchio, Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche, Neurochirurgiche e del Comportamento, Universita' di Siena, Policlinico “Le Scotte”, Viale Bracci, I-53100 Siena, Italy.

Received 12 June 2009 ,Revised 21 July 2009 ,Accepted 26 July 2009.

References 

  1. Joels M. Corticosteroid effects in the brain: U-shape it. Trends Pharmacol Sci. 2006;27:244–250
  2. Paul SM, Purdy RH. Neuroactive steroids. FASEB J. 1992;6:2311–2322
  3. Haller J, Mikics E, Makara GB. The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system: a critical evaluation of findings. Front Neuroendocrinol. 2008;29:273–291
  4. de Quervain DJ, Roozendaal B, Nitsch RM, McGaugh JL, Hock C. Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nature Neurosci. 2000;3:313–314
  5. Lupien SJ, Maheu F, Tu M, Fiocco A, Schramek TE. The effects of stress and stress hormones on human cognition: implications for the field of brain and cognition. Brain Cognit. 2007;65:209–237
  6. Friess E, Tagaya H, Grethe C, Trachsel L, Holsboer F. Acute cortisol administration promotes sleep intensity in man. Neuropsychopharmacology. 2004;29:598–604
  7. Abercrombie HC, Kalin NH, Davidson RJ. Acute cortisol elevations cause heightened arousal ratings of objectively nonarousing stimuli. Emotion. 2005;5:354–359
  8. Piazza PV, Rouge-Pont F, Deroche V, Maccari S, Simon H, Le Moal M. (1996) Glucocorticoids have state-dependent stimulant effects on the mesencephalic dopaminergic transmission. Proc Natl Acad Sci U S A. 1996;93:8716–8720
  9. Rose JD, Marrs GS, Moore FL. Rapid, corticosterone-induced disruption of medullary sensorimotor integration related to suppression of amplectic clasping in behaving roughskin newts (Taricha granulosa). Horm Behav. 1998;34:268–282
  10. Remage-Healey L, Bass AH. Rapid, hierarchical modulation of vocal patterning by steroid hormones. J Neurosci. 2004;24:5892–5900
  11. Sale MV, Ridding MC, Nordstrom MA. Cortisol inhibits neuroplasticity induction in human motor cortex. J Neurosci. 2008;28:8285–8293
  12. de Kloet ER, Karst H, Joels M. Corticosteroid hormones in the central stress response: quick-and-slow. Front Neuroendocrinol. 2008;29:268–272
  13. Makara GB, Haller J. Non-genomic effects of glucocorticoids in the neural system: evidence, mechanisms and implications. Prog Neurobiol. 2001;65:367–390
  14. Patel PD, Lopez JF, Lyons DM, Burke S, Wallace M, Schatzberg AF. Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain. J Psychiatr Res. 2000;34:383–392
  15. Sanchez MM, Young LJ, Plotsky PM, Insel TR. Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci. 2000;20:4657–4668
  16. Ziemann U. TMS and drugs. Clin Neurophysiol. 2004;115:1717–1729
  17. Florian J, Muller-Dahlhaus M, Liu Y, Ziemann U. Inhibitory circuits and the nature of their interactions in the human motor cortex a pharmacological TMS study. J Physiol. 2008;586:495–514
  18. Stromberg J, Backstrom T, Lundgren P. Rapid non-genomic effect of glucocorticoid metabolites and neurosteroids on the gamma-aminobutyric acid-A receptor. Eur J Neurosci. 2005;21:2083–2088
  19. Teo JT, Terranova C, Swayne O, Greenwood RJ, Rothwell JC. Differing effects of intracortical circuits on plasticity. Exp Brain Res. 2009;193:555–563
  20. Smith MJ, Adams LF, Schmidt PJ, Rubinow DR, Wassermann EM. (2002) Effects of ovarian hormones on human cortical excitability. Ann Neurol. 2002;51:599–603
  21. Ranjit N, Young EA, Raghunathan TE, Kaplan GA. Modeling cortisol rhythms in a population-based study. Psychoneuroendocrinology. 2005;30:615–624
  22. Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS. Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006;1071:410–421
  23. Brunner R, Schaefer D, Hess K, Parzer P, Resch F, Schwab S. Effect of corticosteroids on short-term and long-term memory. Neurology. 2005;64:335–337
  24. Lupien SJ, Gillin CJ, Hauger RL. Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behav Neurosci. 1999;113:420–430
  25. Newcomer JW, Selke G, Melson AK, et al. Decreased memory performance in healthy humans induced by stress-level cortisol treatment. Arch Gen Psychiatry. 1999;56:527–533
  26. van der Kamp W, Zwinderman AH, Ferrari MD, van Dijk JG. Cortical excitability and response variability of transcranial magnetic stimulation. J Clin Neurophysiol. 1996;13:164–171
  27. Ellaway PH, Davey NJ, Maskill DW, Rawlinson SR, Lewis HS, Anissimova NP. (1998) Variability in the amplitude of skeletal muscle responses to magnetic stimulation of the motor cortex in man. Electroencephalogr Clin Neurophysiol. 1998;109:104–113
  28. Kiers L, Cros D, Chiappa KH, Fang J. Variability of motor potentials evoked by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol. 1993;89:415–423
  29. Wassermann EM. Variation in the response to transcranial magnetic brain stimulation in the general population. Clin Neurophysiol. 2002;113:1165–1171
  30. Pitcher JB, Ogston KM, Miles TS. Age and sex differences in human motor cortex input-output characteristics. J Physiol. 2003;546:605–613
  31. Di Lazzaro V, Oliviero A, Pilato F, et al. The physiological basis of transcranial motor cortex stimulation in conscious humans. Clin Neurophysiol. 2004;115:255–266
  32. Di Lazzaro V, Ziemann U, Lemon R. State of art: physiology of transcranial motor cortex stimulation. Brain Stimulation. 2008;1:345–362
  33. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res. 2000;886:172–189
  34. Schridde U, van Luijtelaar G. Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG/Rij rats. Pharmacol Biochem Behav. 2004;78:369–375
  35. Joels M, Karst H, DeRijk R, de Kloet ER. The coming out of the brain mineralocorticoid receptor. Trend Neurosci. 2008;31:1–7
  36. Buchanan TW, Lovallo WR. Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology. 2001;26:307–317
  37. Yulmetyev R, Gafarov F, Hanggi P, Nigmatullin R, Kayumov S. Possibility between earthquake and explosion seismogram differentiation by discrete stochastic non-Markov processes and local Hurst exponent analysis. Phys Rev E Stat Nonlin Soft Matter Phys. 2001;64:066132
  38. Ermentrout GB, Galan RF, Urban NN. Reliability, synchrony and noise. Trend Neurosci. 2008;31:428–434
  39. Mainen ZF, Sejnowski TJ. Reliability of spike timing in neocortical neurons. Science. 1995;268:1503–1506
  40. Baker SN. Oscillatory interactions between sensorimotor cortex and the periphery. Curr Opin Neurobiol. 2007;17:649–655
  41. Hanggi P. Stochastic resonance in biology: how noise can enhance detection of weak signals and help improve biological information processing. Chemphyschem. 2002;3:285–290
  42. Harris CM, Wolpert DM. Signal-dependent noise determines motor planning. Nature. 1998;394:780–784
  43. Harris CM, Wolpert DM. The main sequence of saccades optimizes speed-accuracy trade-off. Biol Cybern. 2006;95:21–29
  44. Terney D, Chaieb L, Moliadze V, Antal A, Paulus W. Increasing human brain excitability by transcranial high-frequency random noise stimulation. J Neurosci. 2008;28:14147–14155
  45. Winfree AT. The geometry of biological time. New York: Springer-Verlag; 1980;
  46. Bruno RM, Sakmann B. Cortex is driven by weak but synchronously active thalamocortical synapses. Science. 2006;312:1622–1627
  47. Wang XJ, Buzsaki G. Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model. J Neurosci. 1996;16:6402–6413
  48. Ni Z, Chen R. Short-interval intracortical inhibition: a complex measure. Clin Neurophysiol. 2008;119:2175–2176
  49. Biggio G, Concas A, Serra M, et al. Stress and beta-carbolines decrease the density of low affinity GABA binding sites: an effect reversed by diazepam. Brain Res. 1984;305:13–18
  50. Drugan RC, Morrow AL, Weizman R, et al. Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. Brain Res. 1989;487:45–51
  51. Sanes JN, Donoghue JP. Plasticity and primary motor cortex. Annu Rev Neurosci. 2000;23:393–415
  52. Ziemann U, Meintzschel F, Korchounov A, Ilic TV. Pharmacological modulation of plasticity in the human motor cortex. Neurorehabil Neural Repair. 2006;20:243–251
  53. Ziemann U, Muellbacher W, Hallett M, Cohen LG. Modulation of practice-dependent plasticity in human motor cortex. Brain. 2001;124:1171–1181
  54. Davies CH, Davies SN, Collingridge GL. Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J Physiol. 1990;424:513–531
  55. McDonnell MN, Orekhov Y, Ziemann U. The role of GABA(B) receptors in intracortical inhibition in the human motor cortex. Exp Brain Res. 2006;173:86–93
  56. Coluccia D, Wolf OT, Kollias S, Roozendaal B, Forster A, de Quervain DJ. Glucocorticoid therapy-induced memory deficits: acute versus chronic effects. J Neurosci. 2008;28:3474–3478
  57. Cohen JD, Perlstein WM, Braver TS, et al. Temporal dynamics of brain activation during a working memory task. Nature. 1997;386:604–608
  58. Mazzocchio R, Gelli F, Del Santo F, Popa T, Rossi A. Dynamic changes in cortical and spinal activities with different representations of isometric motor actions and efforts. Brain Stimulation. 2008;1:33–43
  59. Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol. 2004;55:400–409

 This study was supported by a grant from the University of Siena (Piano di Ateneo per la Ricerca, PAR 2007). There are no biomedical financial interests or potential conflicts of interest.

PII: S1935-861X(09)00080-1

doi: 10.1016/j.brs.2009.07.004

BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 3, Issue 3 , Pages 131-139 , July 2010

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