BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 3, Issue 3 , Pages 161-169 , July 2010

Long-lasting inhibition of cerebellar output

  • T. Popa

      Affiliations

    • ER6 University of Pierre et Marie Curie (University of Paris 06), Paris, France
    • Corresponding Author InformationCorrespondence: Dr. Traian Popa, ER6 UPMC (Univ Paris 06), Service de Réadaptation Fonctionnelle, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75651 Paris Cedex 13, France.
    • ,
  • M. Russo

      Affiliations

    • ER6 University of Pierre et Marie Curie (University of Paris 06), Paris, France
    • Department of Neuroscience, Psychiatric, and Anestesiologic Sciences, University of Messina, Messina, Italy
    • ,
  • S. Meunier

      Affiliations

    • ER6 University of Pierre et Marie Curie (University of Paris 06), Paris, France

Received 19 June 2009 ,Revised 28 September 2009 ,Accepted 6 October 2009.

References 

  1. Ito M. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev. 2001;81(3):1143–1195
  2. Logan GD. Executive control of thought and action. Acta Psychol (Amst). 1985;60(2-3):193–210
  3. Ugawa Y, Day BL, Rothwell JC, Thompson PD, Merton PA, Marsden CD. Modulation of motor cortical excitability by electrical stimulation over the cerebellum in man. J Physiol. 1991;441:57–72
  4. Ugawa Y, Uesaka Y, Terao Y, Hanajima R, Kanazawa I. Magnetic stimulation over the cerebellum in humans. Ann Neurol. 1995;37(6):703–713
  5. Pinto AD, Chen R. Suppression of the motor cortex by magnetic stimulation of the cerebellum. Exp Brain Res. 2001;140(4):505–510
  6. Daskalakis ZJ, Paradiso GO, Christensen BK, Fitzgerald PB, Gunraj C, Chen R. Exploring the connectivity between the cerebellum and motor cortex in humans. J Physiol. 2004;557(Pt 2):689–700
  7. Gerschlager W, Christensen LO, Bestmann S, Rothwell JC. rTMS over the cerebellum can increase corticospinal excitability through a spinal mechanism involving activation of peripheral nerve fibres. Clin Neurophysiol. 2002;113(9):1435–1440
  8. Fierro B, Giglia G, Palermo A, Pecoraro C, Scalia S, Brighina F. Modulatory effects of 1 Hz rTMS over the cerebellum on motor cortex excitability. Exp Brain Res. 2007;176(3):440–447
  9. Oliveri M, Koch G, Torriero S, Caltagirone C. Increased facilitation of the primary motor cortex following 1 Hz repetitive transcranial magnetic stimulation of the contralateral cerebellum in normal humans. Neurosci Lett. 2005;376(3):188–193
  10. Miall RC, Christensen LO. The effect of rTMS over the cerebellum in normal human volunteers on peg-board movement performance. Neurosci Lett. 2004;371(2-3):185–189
  11. Miall RC, Christensen LO, Cain O, Stanley J. Disruption of state estimation in the human lateral cerebellum. PLoS Biol. 2007;5(11):e316
  12. Petrosini L. “Do what I do” and “do how I do”: different components of imitative learning are mediated by different neural structures. Neuroscientist. 2007;13(4):335–348
  13. Del Olmo MF, Cheeran B, Koch G, Rothwell JC. Role of the cerebellum in externally paced rhythmic finger movements. J Neurophysiol. 2007;98(1):145–152
  14. Torriero S, Oliveri M, Koch G, Caltagirone C, Petrosini L. Interference of left and right cerebellar rTMS with procedural learning. J Cogn Neurosci. 2004;16(9):1605–1611
  15. Allen GI, Gilbert PF, Yin TC. Convergence of cerebral inputs onto dentate neurons in monkey. Exp Brain Res. 1978;32(2):151–170
  16. Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron. 2005;45(2):201–206
  17. Hess G, Donoghue JP. Long-term potentiation and long-term depression of horizontal connections in rat motor cortex. Acta Neurobiol Exp (Wars). 1996;56(1):397–405
  18. Koch G, Mori F, Marconi B, et al. Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum. Clin Neurophysiol. 2008;119(11):2559–2569
  19. Kaneko K, Kawai S, Fuchigami Y, Morita H, Ofuji A. The effect of current direction induced by transcranial magnetic stimulation on the corticospinal excitability in human brain. Electroencephalogr Clin Neurophysiol. 1996;101(6):478–482
  20. Werhahn KJ, Fong JK, Meyer BU, et al. The effect of magnetic coil orientation on the latency of surface EMG and single motor unit responses in the first dorsal interosseous muscle. Electroencephalogr Clin Neurophysiol. 1994;93(2):138–146
  21. Stoodley CJ, Schmahmann JD. Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. NeuroImage. 2009;44(2):489–501
  22. Theoret H, Haque J, Pascual-Leone A. Increased variability of paced finger tapping accuracy following repetitive magnetic stimulation of the cerebellum in humans. Neurosci Lett. 2001;306(1-2):29–32
  23. Rossini PM, Barker AT, Berardelli A, et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application: report of an IFCN committee. Electroencephalogr Clin Neurophysiol. 1994;91(2):79–92
  24. Stokes MG, Chambers CD, Gould IC, et al. Simple metric for scaling motor threshold based on scalp-cortex distance: application to studies using transcranial magnetic stimulation. J Neurophysiol. 2005;94(6):4520–4527
  25. Rothwell JC. Techniques and mechanisms of action of transcranial stimulation of the human motor cortex. J Neurosci Methods. 1997;74(2):113–122
  26. Wagner T, Valero-Cabre A, Pascual-Leone A. Noninvasive human brain stimulation. Annu Rev Biomed Eng. 2007;9:527–565
  27. Allen GI, Tsukahara N. Cerebrocerebellar communication systems. Physiolog Rev. 1974;54(4):957–1006
  28. Hoover JE, Strick PL. The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1. J Neurosci. 1999;19(4):1446–1463
  29. Na J, Kakei S, Shinoda Y. Cerebellar input to corticothalamic neurons in layers V and VI in the motor cortex. Neurosci Res. 1997;28(1):77–91
  30. Sasaki K, Kawaguchi S, Oka H, Sakai M, Mizuno N. Electrophysiological studies on the cerebellocerebral projections in monkeys. Exp Brain Res. 1976;24(5):495–507
  31. Shinoda Y, Kakei S, Futami T, Wannier T. Thalamocortical organization in the cerebello-thalamo-cortical system. Cereb Cortex. 1993;3(5):421–429
  32. Evrard HC, Craig AD. Retrograde analysis of the cerebellar projections to the posteroventral part of the ventral lateral thalamic nucleus in the macaque monkey. J Comp Neurol. 2008;508(2):286–314
  33. Dum RP, Strick PL. An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex. J Neurophysiol. 2003;89(1):634–639
  34. Angaut P, Cicirata F. [Anatomo-functional organization of the neocerebellar control pathways on the cerebral motor cortex]. Rev Neurol. 1994;150(1):39–45
  35. Shinoda Y, Futami T, Kano M. Synaptic organization of the cerebello-thalamo-cerebral pathway in the cat: II, input-output organization of single thalamocortical neurons in the ventrolateral thalamus. Neurosci Res. 1985;2(3):157–180
  36. Rispal-Padel L, Grangetto A. The cerebello-thalamo-cortical pathway: topographical investigation at the unitary level in the cat. Exp Brain Res. 1977;28(1–2):101–123
  37. Kelly RM, Strick PL. Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J Neurosci. 2003;23(23):8432–8444
  38. Lu X, Miyachi S, Ito Y, Nambu A, Takada M. Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of primary motor cortex. Eur J Neurosci. 2007;25(8):2374–2382
  39. Middleton FA, Strick PL. Cerebellar projections to the prefrontal cortex of the primate. J Neurosci. 2001;21(2):700–712
  40. Ramnani N. The primate cortico-cerebellar system: anatomy and function. Nature Rev. 2006;7(7):511–522
  41. Aumann TD, Rawson JA, Pichitpornchai C, Horne MK. Projections from the cerebellar interposed and dorsal column nuclei to the thalamus in the rat: a double anterograde labelling study. J Comp Neurol. 1996;368(4):608–619
  42. Rispal-Padel L, Harnois C, Troiani D. Converging cerebellofugal inputs to the thalamus: I, mapping of monosynaptic field potentials in the ventrolateral nucleus of the thalamus. Exp Brain Res. 1987;68(1):47–58
  43. Rispal-Padel L, Troiani D, Harnois C. Converging cerebellofugal inputs to the thalamus: II, analysis and topography of thalamic EPSPs induced by convergent monosynaptic interpositus and dentate inputs. Exp Brain Res. 1987;68(1):59–72
  44. Middleton FA, Strick PL. Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res. 2000;31(2-3):236–250
  45. Aumann TD, Redman SJ, Horne MK. Long-term potentiation across rat cerebello-thalamic synapses in vitro. Neurosci Lett. 2000;287(2):151–155
  46. Rispal-Padel L, Meftah EM. Changes in motor responses induced by cerebellar stimulation during classical forelimb flexion conditioning in cat. J Neurophysiol. 1992;68(3):908–926
  47. Aumann TD, Horne MK. Ultrastructural change at rat cerebellothalamic synapses associated with volitional motor adaptation. J Comp Neurol. 1999;409(1):71–84
  48. Aumann TD. Cerebello-thalamic synapses and motor adaptation. Cerebellum (London). 2002;1(1):69–77
  49. Werhahn KJ, Taylor J, Ridding M, Meyer BU, Rothwell JC. Effect of transcranial magnetic stimulation over the cerebellum on the excitability of human motor cortex. Electroencephalogr Clin Neurophysiol. 1996;101(1):58–66
  50. Galea JM, Jayaram G, Ajagbe L, Celnik P. Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. J Neurosci. 2009;29(28):9115–9222
  51. Cicirata F, Zappala A, Serapide MF, Parenti R, Panto MR, Paz C. Different pontine projections to the two sides of the cerebellum. Brain Res Brain Res Rev. 2005;49(2):280–294
  52. Murphy MG, Tolbert DL. Autoradiographic demonstration of cerebellar commissural system. Surg Forum. 1975;26:465–467
  53. Rosina A, Provini L. Pontocerebellar system linking the two hemispheres by intracerebellar branching. Brain Res. 1984;296(2):365–369
  54. Rosina A, Provini L, Bentivoglio M, Kuypers HG. Ponto-neocerebellar axonal branching as revealed by double fluorescent retrograde labeling technique. Brain Res. 1980;195(2):461–466
  55. Bantli H, Bloedel JR, Tolbert D. Activation of neurons in the cerebellar nuclei and ascending reticular formation by stimulation of the cerebellar surface. J Neurosurg. 1976;45(5):539–554
  56. Brinkman C. Lesions in supplementary motor area interfere with a monkey's performance of a bimanual coordination task. Neurosci Lett. 1981;27(3):267–270
  57. Brinkman J, Kuypers HG. Cerebral control of contralateral and ipsilateral arm, hand and finger movements in the split-brain rhesus monkey. Brain. 1973;96(4):653–674
  58. Aumann TD, Horne MK. Ramification and termination of single axons in the cerebellothalamic pathway of the rat. J Comp Neurol. 1996;376(3):420–430
  59. Middleton FA, Strick PL. Cerebellar output channels. Int Rev Neurobiol. 1997;41:61–82
  60. Rispal-Padel L. [Contribution of cerebellar efferents to the organization of motor synergy]. Rev Neurol. 1993;149(11):716–727
  61. Koch G, Brusa L, Carrillo F, et al. Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease. Neurology. 2009;73(2):113–119
  62. Gironell A, Kulisevsky J, Lorenzo J, Barbanoj M, Pascual-Sedano B, Otermin P. Transcranial magnetic stimulation of the cerebellum in essential tremor: a controlled study. Arch Neurol. 2002;59(3):413–417
  63. Khedr EM, Rothwell JC, Shawky OA, Ahmed MA, Hamdy A. Effect of daily repetitive transcranial magnetic stimulation on motor performance in Parkinson's disease. Mov Disord. 2006;21(12):2201–2205
  64. Lomarev MP, Kanchana S, Bara-Jimenez W, Iyer M, Wassermann EM, Hallett M. Placebo-controlled study of rTMS for the treatment of Parkinson's disease. Mov Disord. 2006;21(3):325–331
  65. Miranda PC, Lomarev M, Hallett M. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol. 2006;117(7):1623–1629
  66. Brighina F, Romano M, Giglia G, et al. Effects of cerebellar TMS on motor cortex of patients with focal dystonia: a preliminary report. Exp Brain Res. 2009;192(4):651–656
  67. Brighina F, Daniele O, Piazza A, Giglia G, Fierro B. Hemispheric cerebellar rTMS to treat drug-resistant epilepsy: case reports. Neurosci Lett. 2006;397(3):229–233

 This work was supported by a scholarship of the “Pierre et Marie Curie” University, Paris 06, and by a Bourse Santé Mentale Neurologie of the Lilly Institute, France.

PII: S1935-861X(09)00105-3

doi: 10.1016/j.brs.2009.10.001

BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 3, Issue 3 , Pages 161-169 , July 2010

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