Infrared radiation has potential antidepressant and anxiolytic effects in animal model of depression and anxiety

Tanaka, Yoshihiro; Akiyoshi, Jotaro; Kawahara, Yoshinari; Ishitobi, Yoshinobu; Hatano, Koji; Hoaki, Nobuhiko; Mori, Ayumi; Goto, Shinjiro; Tsuru, Jusen; Matsushita, Hirotaka; Hanada, Hiroaki; Kodama, Kensuke; Isogawa, Koichi; Kitamura, Hirokazu; Fujikura, Yoshihisa

doi:10.1016/j.brs.2010.04.001

« Previous Next »BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
Volume 4, Issue 2 , Pages 71-76, April 2011

Infrared radiation has potential antidepressant and anxiolytic effects in animal model of depression and anxiety

Yoshihiro Tanaka
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Jotaro Akiyoshi
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
- Correspondence to: Jotaro Akiyoshi, Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Oita 879-5593, Japan.
Yoshinari Kawahara
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Yoshinobu Ishitobi
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Koji Hatano
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Nobuhiko Hoaki
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Ayumi Mori
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Shinjiro Goto
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Jusen Tsuru
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Hirotaka Matsushita
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Hiroaki Hanada
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Kensuke Kodama
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Koichi Isogawa
- Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Hirokazu Kitamura
- Department of Molecular Anatomy, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan
Yoshihisa Fujikura
- Department of Molecular Anatomy, Oita University Faculty of Medicine, Hasama-Machi, Yufu-Shi, Oita, Japan

Received 24 December 2009; received in revised form 27 March 2010; accepted 12 April 2010. published online 10 May 2010.

Background

Bright light therapy has been shown to have antidepressant and anxiolytic effects in humans.

Objective

The antidepressant and anxiolytic effects of infrared radiation were evaluated using an experimental animal model.

Methods

Rats were randomly assigned to either an acutely or chronically exposed infrared radiation group or to a nonexposed control group. Acutely exposed rats were treated with an infrared radiation machine for one session, whereas chronically exposed animals were treated with an infrared radiation for 10 sessions. Control group rats were exposed to the sound of the infrared radiation machine as a sham treatment. After infrared radiation or control exposure, rats underwent behavioral evaluation, including elevated plus maze test, light/dark box, and forced swim test.

Results

Chronic infrared radiation exposure decreased indicators of depression- and anxiety-like behavior. No significant effect on general locomotor activity was observed. The number of BrdU-positive cells in CA1 of the hippocampus was significantly increased in both acutely and chronically exposed infrared radiation groups compared with the control group.