Abstract
Background
Verbal fluency relies on the coordinated activity between left frontal and temporal
areas. Patients with Parkinson’s disease (PD) present phonemic and semantic fluency
deficits. Recent studies suggest that transcranial direct current stimulation (tDCS)
enhances adaptative patterns of brain activity between functionally connected areas.
Objective
The aim of this study was to assess the differences in the effects induced by tDCS
applied to frontal and temporo-parietal areas on phonemic and semantic fluency functional
networks in patients with PD.
Method
Sixteen patients were randomized to receive tDCS to left dorsolateral prefrontal cortex
(DLPFC) and left temporo-parietal cortex (TPC) in a counterbalanced order. Immediately
following stimulation, patients underwent a verbal fluency paradigm inside a fMRI
scanner. Changes induced by tDCS in activation and deactivation task-related pattern
networks were studied using free-model independent component analyses (ICA).
Results
Functional connectivity in verbal fluency and deactivation task-related networks was
significantly more enhanced by tDCS to DLPFC than to TPC. In addition, DLPFC tDCS
increased performance on the phonemic fluency task, after adjusting for baseline phonemic
performance.
Conclusions
These findings provide evidence that tDCS to specific brain regions induces changes
in large scale functional networks that underlay behavioural effects, and suggest
that tDCS might be useful to enhance phonemic fluency in PD.
Keywords
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Article info
Publication history
Published online: February 23, 2012
Accepted:
January 17,
2012
Received in revised form:
December 26,
2011
Received:
November 20,
2011
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
