Abstract
Background
Changes in motivational processing may play a role in weight gain and other non-motor
side effects in Parkinson's disease (PD) patients treated with deep brain stimulation
of the subthalamic nucleus.
Objective/hypothesis
We aimed to assess changes in aversive and appetitive motivational activation using
modulation of the acoustic blink reflex (ABR) by rewarding and aversive stimuli.
Methods
ABR elicited during the viewing of erotic, food, aversive and neutral pictures was
recorded in 11 off-medicated patients with the subthalamic stimulation switched ON
and OFF, and in 11 control subjects.
Results
ABR to erotic stimuli was larger in patients in the ON compared to the OFF condition
and controls (P < 0.01). Aversive stimuli caused a larger increase in the ABR in patients with the
ON condition than in controls (P < 0.05). Additionally, we found a negative correlation of the ABR magnitude to food
pictures in the ON condition with weight gain following subthalamic stimulation (P < 0.01, after adjustment to OFF condition).
Conclusions
Our results suggest that subthalamic stimulation affects motivational processing.
Subthalamic stimulation may disturb appetitive engagement by erotic cues and increase
aversive activation in PD patients. Additionally, postoperative weight gain may be
related to changes in the processing of food cues due to subthalamic stimulation.
Keywords
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Article info
Publication history
Published online: April 08, 2013
Accepted:
March 20,
2013
Received in revised form:
March 19,
2013
Received:
December 12,
2012
Footnotes
Financial disclosure: This work was supported by the Czech Science Foundation (GACR 309/09/1145), by the Czech Ministry of Health: IGA MZ ČR NT12282-5/2011, IGA MZ ČR NT12288-5/2011, IGA MZ ČR NT 11331-6/2010, by the Czech Ministry of Education (VZ 0021620849), by Czech Technical University in Prague, grant SGS10/279/OHK3/3T/13 and by the Charles University in Prague (PRVOUK-P26/LF1/4). Robert Jech, Dušan Urgošík, and Evžen Růžička received consulting fees from Medtronic.
Identification
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© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
