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Sex, Food and Threat: Startling Changes after Subthalamic Stimulation in Parkinson's Disease

  • Tereza Serranová
    Correspondence
    Corresponding author. Department of Neurology, First Medical Faculty, Charles University in Prague, Kateřinská 30, 120 00, Praha 2, Czech Republic. Tel.: +420 224 965550; fax: +420 224 922678.
    Affiliations
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
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  • Tomáš Sieger
    Affiliations
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic

    Department of Cybernetics, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic
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  • Petr Dušek
    Affiliations
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
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  • Filip Růžička
    Affiliations
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
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  • Dušan Urgošík
    Affiliations
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic

    Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic
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  • Evžen Růžička
    Affiliations
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
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  • Josep Valls-Solé
    Affiliations
    Neurology Service, Hospital Clíınic, Facultad de Medicina, Universitat de Barcelona, Spain
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  • Robert Jech
    Affiliations
    Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
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Published:April 08, 2013DOI:https://doi.org/10.1016/j.brs.2013.03.009

      Abstract

      Background

      Changes in motivational processing may play a role in weight gain and other non-motor side effects in Parkinson's disease (PD) patients treated with deep brain stimulation of the subthalamic nucleus.

      Objective/hypothesis

      We aimed to assess changes in aversive and appetitive motivational activation using modulation of the acoustic blink reflex (ABR) by rewarding and aversive stimuli.

      Methods

      ABR elicited during the viewing of erotic, food, aversive and neutral pictures was recorded in 11 off-medicated patients with the subthalamic stimulation switched ON and OFF, and in 11 control subjects.

      Results

      ABR to erotic stimuli was larger in patients in the ON compared to the OFF condition and controls (P < 0.01). Aversive stimuli caused a larger increase in the ABR in patients with the ON condition than in controls (P < 0.05). Additionally, we found a negative correlation of the ABR magnitude to food pictures in the ON condition with weight gain following subthalamic stimulation (P < 0.01, after adjustment to OFF condition).

      Conclusions

      Our results suggest that subthalamic stimulation affects motivational processing. Subthalamic stimulation may disturb appetitive engagement by erotic cues and increase aversive activation in PD patients. Additionally, postoperative weight gain may be related to changes in the processing of food cues due to subthalamic stimulation.

      Keywords

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