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Transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex modulates declarative memory

  • Amir Homayoun Javadi
    Correspondence
    Correspondence: Amir Homayoun Javadi, Forschungsbereich Systemische Neurowissenschaften, Würzburger Str. 35, 01187 Dresden, Germany.
    Affiliations
    Institute of Cognitive Neuroscience (ICN), University College London (UCL), London, United Kingdom

    Neuroimaging Center, Section of Systems Neuroscience, Technische Universität Dresden, Dresden, Germany
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  • Vincent Walsh
    Affiliations
    Institute of Cognitive Neuroscience (ICN), University College London (UCL), London, United Kingdom

    Division of Psychology and Language Sciences, University College London (UCL), London, United Kingdom
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      Background

      Previous studies have claimed that weak transcranial direct current stimulation (tDCS) induces persisting activity changes in the human motor cortex and working memory, but to date no studies have evaluated the effects of tDCS on declarative memory.

      Objective

      Our aim was to determine whether anodal and cathodal transcranial direct current stimulation would differentially modify performance in a word memorization task during encoding or recognition when administered over the left dorsolateral prefrontal cortex (DLPFC).

      Methods

      In two experiments, 32 participants underwent a series of word memorization tasks. This task was performed during sham, anodal, and cathodal stimulation applied over the left DLPFC. Moreover, participants in the first experiment performed the same task with anodal tDCS of the primary motor cortex (M1).

      Results

      During encoding, anodal stimulation of the left DLPFC improved memory, whereas cathodal stimulation of the same area impaired memory performance in later recognition. Anodal stimulation of M1 had no effect on later recognition. During recognition cathodal stimulation of the left DLPFC impaired recognition compared with sham stimulation of the same area and anodal stimulation had a trend toward improving the recognition.

      Conclusions

      The results indicated that active stimulation of the left DLPFC leads to an enhancement or impairment of verbal memorization depending on the polarity of the stimulation. Furthermore, this effect was specific to the site of stimulation.

      Keywords

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