There is considerable evidence for clinical and behavioral efficacy of transcranial
alternating current stimulation (tACS). The effects range from suppressing Parkinsonian
tremors to augmenting human learning and memory. Despite widespread use, the neurobiological
mechanism of actions of tACS on the brain is unclear. We have taken a threefold approach
to probe tACS mechanisms. First, we examined the behavioral effects of tACS on human
motion perception. Second, we used known motion models to generate predictions about
neural mechanisms that could produce the effects. Third, we tested these predictions
by directly measuring tACS-induced neural activity changes in the macaque brain.
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© 2014 Published by Elsevier Inc.