We report the first clinical case of long-term low frequency vagus nerve stimulation
(VNS) in a patient with Crohn's disease (CD), a chronic inflammatory disorder characterized
by relapsing and remitting periods of gastrointestinal inflammation [
[1]
]. There is no definitive cure of CD and there is a strong need for an efficient treatment
inducing sustained remission. We have shown, in an experimental model of CD, that
chronic low frequency VNS activates the cholinergic anti-inflammatory pathway through
vagal efferents [
[2]
]. VNS is thus a therapeutic option for CD though it has only been used at high frequency
in epilepsy and depression [
[3]
]. Long-term low frequency (10 Hz) VNS has never been tested in CD and its central
effect remains unknown. Here, we share our first evaluation of the effect of 10 Hz
VNS in CD on both brain and parasympathetic nervous system.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: August 06, 2014
Accepted:
August 1,
2014
Received in revised form:
July 29,
2014
Received:
July 17,
2014
Footnotes
Funding: This work was financially supported by the Appel à projet (AAP) translationnel INSERM-DGOS 2011.
Conflict of interest statement: None of the authors has any conflict of interest to disclose.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
