Daily left prefrontal rTMS is being increasingly used for the acute treatment of unipolar
and bipolar depression, with acute remission rates in open-label studies ranging from
30 to 60% [
1
,
2
]. The treatment also appears to have reasonable 6 and 12-month durability [
3
,
4
]. However, some patients require periodic maintenance treatments in order to not relapse
back into a complete episode [
[5]
]. There is much discussion but little data concerning the safety of long-term maintenance
TMS, or how much exposure to TMS an individual can have over a lifetime [
[6]
]. We present the case of a young woman who may have the highest TMS exposure to date
(7 years, 2 million stimuli), who is largely depression free without safety issues.To read this article in full you will need to make a payment
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References
- Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial.Arch Gen Psychiatry. 2010; 67: 507-516
- Transcranial magnetic stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes in clinical practice.Depress Anxiety. 2012; 29: 587-596
- Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study.Brain Stimul. 2010; 3: 187-199
- Long-term efficacy of repeated daily prefrontal transcranial magnetic stimulation (TMS) in treatment-resistant depression.Depress Anxiety. 2012; 29: 883-890
- Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?.Depress Anxiety. 2004; 20: 98-100
- Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research.Clin Neurophysiol. 2009; 120: 2008-2039
- Safety, tolerability, and effectiveness of high doses of adjunctive daily left prefrontal repetitive transcranial magnetic stimulation for treatment-resistant depression in a clinical setting.J ECT. 2011; 27: 18-25
Article info
Publication history
Published online: October 07, 2014
Accepted:
September 9,
2014
Received in revised form:
September 2,
2014
Received:
July 28,
2014
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
