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A Case for rTMS in Late Life Depression with Comorbid Alzheimer's Dementia

Published:December 10, 2015DOI:https://doi.org/10.1016/j.brs.2015.11.002
      Antidepressant medications have limited efficacy and significant safety concerns in geriatric depression [
      • Alexopoulos GS
      • Kelly Jr, RE
      Research advances in geriatric depression.
      ]. Repetitive transcranial magnetic stimulation (rTMS) is an effective tool in the treatment of major depressive disorder (MDD), is non-systemic and side effects are few and generally mild [
      • George MS
      • Post RM
      Daily left prefrontal repetitive transcranial magnetic stimulation for acute treatment of medication-resistant depression.
      ]. However, due to a limited body of literature on the use of rTMS in geriatric patients, and concerns that age-related brain changes incur greater treatment resistance, patients with late life depression are frequently denied a safe and potentially life-saving antidepressant treatment.
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