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Case Report: Successful Treatment of Therapy-Resistant OCD With Application of Transcranial Alternating Current Stimulation (tACS)

Published:March 10, 2016DOI:https://doi.org/10.1016/j.brs.2016.03.005
      Obsessive compulsive disorder (OCD) is characterized by recurrent intrusive thoughts and impulses (obsessions), followed by repetitive thinking or behavioral acting (compulsions) which reduces the obsession-associated anxiety level. Without treatment, severity and daily duration of compulsive symptoms often increase, eventually resulting in marked social impairment and loss of employment. Psychopharmacological treatment with serotonin re-uptake inhibitors, and tricyclic antidepressants like clomipramine, which seems to be as effective as cognitive behavior therapy (CBT) leads to symptom reduction in 40–70%, and full recovery in approximately 25% of patients [
      • Fisher P.J.
      • Wells A.
      How effective and cognitive and behavioral treatments for obsessive-compulsive disorder? A clinical significance analysis.
      ]. However, nonresponding patients [
      • Boschen M.J.
      • Drummond L.M.
      • Pillay A.
      Treatment of severe, treatment refractory obsessive compulsive disorder: a study of inpatient and community treatment.
      ] are usually severely ill and socially isolated without real chance for substantial clinical improvement.
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