- •Transcranial direct current stimulation (tDCS) has been evaluated in a limited number of pharmacoresistant epilepsy patients, but treatment parameters remain undefined.
- •Safety and efficacy of two cathodal tDCS protocols were evaluated in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).
- •Three and five sessions decreased seizure frequency and interictal epileptiform discharges in MTLE-HS patients, compared to placebo.
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Submission statements: All authors have seen and agree with the contents of the manuscript.
Daniel San-Juan, M.D., principal author takes full responsibility for the data, the analyses and interpretation, and the conduct of the research; also Daniel San-Juan, M.D. has full access to all of the data; and has the right to publish any and all data separate and apart from any sponsor.
Daniel San-Juan, M.D., principal author takes full responsibility for clinical trial data and the data results will be deposited in a clinical trials database (clinicaltrials.gov with the identifier NCT01763294).
We certify that the submission (aside from an abstract) is not under review at any other publication.
Other information: This study was registered at ClinicalTrials.gov with the identifier NCT01763294, and the name “A Controlled Clinical Trial of Cathodal Transcranial Direct Current Stimulation in Patients with Refractory Epilepsy”. The full trial protocol can be accessed in the Clinical Research Department of the National Institute of Neurology and Neurosurgery in Mexico.