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The role of inhibition in motor performance and learning

      Introduction: Understanding the neurophysiological underpinnings of motor plasticity is of prime importance, not least for developing novel therapeutic approaches after a stroke. There is substantial evidence from animal models to support the hypothesis that modulation of GABA, the major inhibitory neurotransmitter, is a necessary step in motor learning. However, until recently it has been difficult to assess whether GABA is necessary for plasticity in vivo in humans.
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