Introduction: Understanding the neurophysiological underpinnings of motor plasticity is of prime
importance, not least for developing novel therapeutic approaches after a stroke.
There is substantial evidence from animal models to support the hypothesis that modulation
of GABA, the major inhibitory neurotransmitter, is a necessary step in motor learning.
However, until recently it has been difficult to assess whether GABA is necessary
for plasticity in vivo in humans.
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