Introduction: Cerebral microvascular disease (CMD) is characterized by accumulation of ischemic
damage to frontal and subcortical regions of the brain caused by chronic hypoperfusion
relative to metabolic demand. This damage results in a unique clinical phenotype of
cognitive “executive” dysfunction, slow gait and depressed affect. These unique cognitive-motor
symptoms are linked to reduced capacity to effectively modulate cerebral blood flow
and ultimately, activate the fronto-parietal “executive control” brain network in
response to a given task. Noninvasive modulation of neuronal excitability within this
network—via transcranial direct current stimulation (tDCS)—thus holds great promise
as a therapeutic strategy to mitigate the symptoms of CMD.
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© 2017 Published by Elsevier Inc.
