Abstract| Volume 10, ISSUE 2, P469, March 2017

Transcranial direct current stimulation (tDCS) improves cognitive-motor performance in older adults with cerebral microvascular disease

      Introduction: Cerebral microvascular disease (CMD) is characterized by accumulation of ischemic damage to frontal and subcortical regions of the brain caused by chronic hypoperfusion relative to metabolic demand. This damage results in a unique clinical phenotype of cognitive “executive” dysfunction, slow gait and depressed affect. These unique cognitive-motor symptoms are linked to reduced capacity to effectively modulate cerebral blood flow and ultimately, activate the fronto-parietal “executive control” brain network in response to a given task. Noninvasive modulation of neuronal excitability within this network—via transcranial direct current stimulation (tDCS)—thus holds great promise as a therapeutic strategy to mitigate the symptoms of CMD.
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