Abstract| Volume 10, ISSUE 2, P483, March 2017

The efficacy of paired-associative stimulation for inducing neuroplasticity in motor cortex of healthy individuals: a qualitative review

      Introduction: Paired associative stimulation (PAS) is a transcranial magnetic stimulation (TMS) paradigm that assesses neuroplasticity in the human cortex. PAS consists of pairing peripheral nerve stimulation (PNS) with a subsequent TMS repeatedly over the primary motor cortex (M1). To date, PAS is known to be among the most robust methods to induce neuroplasticity in the cerebral cortex. However, inter-individual variabilities in PAS response are well known. This review aims to systematically synthesize the literature on PAS parameters and confounding factors that have significant influences in the induction of neuroplasticity.
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