Introduction: It has long been established that the existence of prior knowledge (or schema representation) to which new information can be related, facilitates memory encoding, consolidation and retrieval. Schema is interpreted as a network of strongly interrelated neocortical representations. Recent studies show the role of the medial prefrontal cortex (mPFC) for establishing a link between representations of objects based on their congruency to either prior knowledge or to each other, thereby facilitating memory functions.
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