Traumatic brain injury (TBI) causes neurologic deficit in 70% of survivors without
a clinically effective therapy. Transcranial direct current stimulation (tDCS) is
a prospective adjunct therapy for TBI but due to limited animal studies the mechanisms
and optimal parameters are unknown. In this pilot study we examined the effects of
repetitive anodal tDCS on cerebral blood flow (CBF) and brain oxygenation after TBI
in mice and evaluated the efficacy in long-term neurologic recovery. Using in-vivo 2-photon laser scanning microscopy (2PLSM) we have shown that tDCS (0.1 mA/15min)
improved microvascular CBF and tissue oxygenation in the pericontusional cortex in
the recovery period after TBI, which was confirmed by global CBF by magnetic resonance
imaging (MRI). Repetitive tDCS (4 weeks, 4 days/ week) significantly improved motor
and cognitive neurologic outcome. tDCS acutely increases CBF and tissue oxygenation
and contributes to improved neurologic recovery after TBI.
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