- •VNS in treatment-resistant depression can help sustain near-permanent remission.
- •VNS was very well tolerated by all patients without any major adverse effects.
- •VNS demonstrates resilience: remission regained after battery/device failure.
- •These patients have heavy family histories of depressive illness and/or alcoholism.
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- Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.Am J Psychiatry. 2006; 163: 1905-1917
- Identification of a claims data “signature” and economic consequences for treatment-resistant depression.J Clin Psychiatry. 2002; 63: 717-726
- Durability of antidepressant response to vagus nerve stimulation (VNS).Int J Neuropsychopharmacol. 2007; 10: 817-826
- Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes.J Clin Psychiatry. 2005; 66: 1097-1104
- Toward an evidence-based, operational definition of treatment-resistant depression: when enough is enough.JAMA Psychiatry. 2017; 74: 9-10
- A 5-year observational study of patients with treatment-resistant depression treated with Vagus Nerve stimulation or treatment as usual: comparison of response, remission, and suicidality.Am J Psychiatry. 2017 March 31; (appiajp201716010034, http://dx.doi.org/10.1176/appi.ajp.2017.16010034)
- Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study.Biol Psychiatry. 2005; 58: 355-363
- Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects.Brain Stimul. 2013; 6: 631-640
- Clinical predictors of ketamine response in treatment-resistant major depression.J Clin Psychiatry. 2014; 75: e417-e423
- Vagus nerve stimulation for depression: a case of a broken lead, depression relapse, revision surgery, and restoration of patient response.Brain Stimul. 2008; 1: 227-228
Published online: June 07, 2017
Accepted: June 2, 2017
Received: May 15, 2017
Published by Elsevier Inc.