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Letter| Volume 11, ISSUE 2, P456-458, March 2018

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A pilot study of subthalamic theta frequency deep brain stimulation for cognitive dysfunction in Parkinson's disease

  • Author Footnotes
    1 Current address: Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave., San Francisco, CA 94143, USA.
    Katherine W. Scangos
    Correspondence
    Corresponding author. Department of Psychiatry, University of California, Davis, 2230 Stockton Blvd., Sacramento, CA 95817, USA.
    Footnotes
    1 Current address: Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave., San Francisco, CA 94143, USA.
    Affiliations
    Department of Psychiatry, University of California, Davis, UC Davis Imaging Research Center, 4701 X Street, Sacramento, CA 95817, USA
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  • Cameron S. Carter
    Affiliations
    Department of Psychiatry, University of California, Davis, UC Davis Imaging Research Center, 4701 X Street, Sacramento, CA 95817, USA
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  • Gene Gurkoff
    Affiliations
    Department of Neurological Surgery, University of California, Davis 4860 Y Street, Suite 3740, Sacramento, CA 95817, USA
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  • Lin Zhang
    Affiliations
    Department of Neurology, University of California, Davis, Lawrence J. Ellison Ambulatory Care Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
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  • Kiarash Shahlaie
    Affiliations
    Department of Neurological Surgery, University of California, Davis 4860 Y Street, Suite 3740, Sacramento, CA 95817, USA
    Search for articles by this author
  • Author Footnotes
    1 Current address: Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave., San Francisco, CA 94143, USA.
Published:November 22, 2017DOI:https://doi.org/10.1016/j.brs.2017.11.014
A pilot study of subthalamic theta frequency deep brain stimulation for cognitive dysfunction in Parkinson's disease
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      Highlights

      • •
        A first look at effect of deep brain stimulation frequency on executive control.
      • •
        5 Hz, but not 130 Hz, stimulation of the subthalamic nucleus improved control.
      • •
        2 days of continuous 5 Hz stimulation did not lead to significant habituation.
      • •
        5 Hz stimulation in cognitive-emotion region of the subthalamic nucleus was safe.
      • •
        5 Hz corticostriatal stimulation may restore task specific oscillatory activity.

      Keywords

      Abbreviations:

      DBS (deep brain stimulation), STN (subthalamic nucleus), PD (Parkinson's disease), BDI (Beck Depression Inventory), NPI (Neuropsychiatric Inventory)
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      Article info

      Publication history

      Published online: November 22, 2017
      Accepted: November 19, 2017
      Received: October 26, 2017

      Identification

      DOI: https://doi.org/10.1016/j.brs.2017.11.014

      Copyright

      © 2017 Elsevier Inc. All rights reserved.

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