Advertisement

A pilot study of subthalamic theta frequency deep brain stimulation for cognitive dysfunction in Parkinson's disease

  • Author Footnotes
    1 Current address: Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave., San Francisco, CA 94143, USA.
    Katherine W. Scangos
    Correspondence
    Corresponding author. Department of Psychiatry, University of California, Davis, 2230 Stockton Blvd., Sacramento, CA 95817, USA.
    Footnotes
    1 Current address: Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave., San Francisco, CA 94143, USA.
    Affiliations
    Department of Psychiatry, University of California, Davis, UC Davis Imaging Research Center, 4701 X Street, Sacramento, CA 95817, USA
    Search for articles by this author
  • Cameron S. Carter
    Affiliations
    Department of Psychiatry, University of California, Davis, UC Davis Imaging Research Center, 4701 X Street, Sacramento, CA 95817, USA
    Search for articles by this author
  • Gene Gurkoff
    Affiliations
    Department of Neurological Surgery, University of California, Davis 4860 Y Street, Suite 3740, Sacramento, CA 95817, USA
    Search for articles by this author
  • Lin Zhang
    Affiliations
    Department of Neurology, University of California, Davis, Lawrence J. Ellison Ambulatory Care Center, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Search for articles by this author
  • Kiarash Shahlaie
    Affiliations
    Department of Neurological Surgery, University of California, Davis 4860 Y Street, Suite 3740, Sacramento, CA 95817, USA
    Search for articles by this author
  • Author Footnotes
    1 Current address: Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave., San Francisco, CA 94143, USA.
Published:November 22, 2017DOI:https://doi.org/10.1016/j.brs.2017.11.014

      Highlights

      • A first look at effect of deep brain stimulation frequency on executive control.
      • 5 Hz, but not 130 Hz, stimulation of the subthalamic nucleus improved control.
      • 2 days of continuous 5 Hz stimulation did not lead to significant habituation.
      • 5 Hz stimulation in cognitive-emotion region of the subthalamic nucleus was safe.
      • 5 Hz corticostriatal stimulation may restore task specific oscillatory activity.

      Keywords

      Abbreviations:

      DBS (deep brain stimulation), STN (subthalamic nucleus), PD (Parkinson's disease), BDI (Beck Depression Inventory), NPI (Neuropsychiatric Inventory)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      References

        • Goldman J.G.
        • Litvan I.
        Mild cognitive impairment in Parkinson's disease.
        Minerva Med. 2011; 102: 441-459
        • Combs H.L.
        • Folley B.S.
        • Berry D.T.
        • Segerstrom S.C.
        • Han D.Y.
        • Anderson-Mooney A.J.
        • et al.
        Cognition and depression following deep brain stimulation of the subthalamic nucleus and globus pallidus pars internus in Parkinson's disease: a meta-analysis.
        Neuropsychol Rev. 2015; 25: 439-454
        • Sauseng P.
        • Griesmayr B.
        • Freunberger R.
        • Klimesch W.
        Control mechanisms in working memory: a possible function of EEG theta oscillations.
        Neurosci Biobehav Rev. 2010; 34: 1015-1022
        • Beck A.T.
        • Ward C.H.
        • Mendelson M.
        • Mock J.
        • Erbaugh J.
        An inventory for measuring depression.
        Arch Gen Psychiatry. 1961; 4: 561-571
        • MacLeod C.M.
        Half a century of research on the Stroop effect: an integrative review.
        Psychol Bull. 1991; 109: 163-203
        • Cummings J.L.
        • Mega M.
        • Gray K.
        • Rosenberg-Thompson S.
        • Carusi D.A.
        • Gornbein J.
        The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia.
        Neurology. 1994; 44: 2308-2314
        • Fahn S.
        • Elton R.
        • Members of the UPDRS Development Committee
        Recent developments in Parkinson's disease. vol. 2. Macmillan Health Care Information, Florham Park, NJ1987: 153-163 (293–304)
        • Kerns J.G.
        • Cohen J.D.
        • MacDonald 3rd, A.W.
        • Johnson M.K.
        • Stenger V.A.
        • Aizenstein H.
        • et al.
        Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia.
        Am J Psychiatry. 2005; 162: 1833-1839
        • Jahanshahi M.
        Effects of deep brain stimulation of the subthalamic nucleus on inhibitory and executive control over prepotent responses in Parkinson's disease.
        Front Syst Neurosci. 2013; 7: 118
        • Lee D.J.
        • Gurkoff G.G.
        • Izadi A.
        • Berman R.F.
        • Ekstrom A.D.
        • Muizelaar J.P.
        • et al.
        Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory after traumatic brain injury.
        J Neurotrauma. 2013; 30: 131-139