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Letter| Volume 11, ISSUE 6, P1393-1394, November 2018

Reliability of single and paired pulse transcranial magnetic stimulation parameters across eight testing sessions

Published:August 18, 2018DOI:https://doi.org/10.1016/j.brs.2018.08.008
      Transcranial magnetic stimulation (TMS) is a popular method for measuring motor cortical excitability in healthy and clinical populations, and is often used as an outcome measure to explore changes following an intervention. It is therefore important that the reliability of these measures is extensively examined and demonstrated. Several studies have sought to explore this [
      • Ngomo S.
      • et al.
      Comparison of transcranial magnetic stimulation measures obtained at rest and under active conditions and their reliability.
      ,
      • Hermsen A.M.
      • et al.
      Test-retest reliability of single and paired pulse transcranial magnetic stimulation parameters in healthy subjects.
      ,
      • Maeda F.
      • et al.
      Inter- and intra-individual variability of paired-pulse curves with transcranial magnetic stimulation (TMS).
      ,
      • Fried P.J.
      • et al.
      Reproducibility of single-pulse, paired-pulse, and intermittent theta-burst TMS measures in healthy aging, Type-2 diabetes, and alzheimer's disease.
      ,
      • Carroll T.J.
      • Riek S.
      • Carson R.G.
      Reliability of the input-output properties of the cortico-spinal pathway obtained from transcranial magnetic and electrical stimulation.
      ], and have typically included assessment of reliability across 2–3 sessions for the following measures: motor threshold (MT); TMS recruitment/input output (IO) curves; short interval intracortical inhibition (SICI); and intracortical facilitation (ICF). These have revealed varying degrees of reliability across the different parameters [
      • Beaulieu L.D.
      • et al.
      Reliability and minimal detectable change of transcranial magnetic stimulation outcomes in healthy adults: a systematic review.
      ]. Here we report the results of an in-depth exploration of TMS measures over an extensive testing period of 8 sessions. We also explore the impact of different data analysis processes.
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