Over the past decade there has been significant advancement in understanding the multitude of ways naltrexone interacts with human physiology. The two main theories purported in literature are suppression of cytokine production by glial cells and transient blockade of the mu- opioid receptor. This case report highlights a chronic pain patient that sustained a wean from high dose opioid regimen utilizing low dose naltrexone. Her daily pain score, as calculated using the Defense and Veterans Pain Rating Scale, was lower after she was weaned from opioids.
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