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Stanford accelerated intelligent neuromodulation therapy for treatment-resistant depression (SAINT-TRD)

      Background: Intermittent theta-burst stimulation (iTBS) is an FDA-approved treatment for treatment-resistant depression (TRD). Typical courses involve daily stimulation sessions for six weeks and average response rates are around 50%. Several studies have demonstrated the safety and potential enhanced efficacy of accelerated theta-burst stimulation. Higher pre-treatment anti-correlation between the stimulated region of the left dorsolateral prefrontal cortex (L-DLPFC) and subcallosal cingulate cortex (SCC) has been associated with better clinical outcome.
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