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Effect Of Low-intensity Pulsed Ultrasound On Epileptiform Discharges In A Penicillin-induced Epilepsy Model In Non-human Primates

  • J. Zou
    Affiliations
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China

    National Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical Uni-versity, China
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  • Y. Guo
    Affiliations
    National Key Clinical Specialty, Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical Uni-versity, China
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  • L. Niu
    Affiliations
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China
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  • L. Meng
    Affiliations
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China
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  • N. Pang
    Affiliations
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China
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  • H. Zheng
    Affiliations
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China
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      Background: Epilepsy is a common neurological disorder that affects more than 50 million people worldwide. It is characterized by recurrent seizures resulting from excessive excitation or inadequate inhibition of neurons Previous studies demonstrated that low-intensity pulsed ultrasound (LIPUS) could suppress the number of epileptic signal bursts observed in electroencephalographic (EEG) recordings in rodents. However, whether ultrasound can inhibit epileptiform discharges in nonhuman primates is unclear.
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