Introduction: Neuronal oscillations reflect brain functions, and also affect computation and communication in local or large-scale brain networks. One of the plausible mechanisms by which neuronal oscillations both reflect and regulate the brain activity is the cross-frequency coupling (CFC). Several studies showed that this feature of neuronal oscillations contributes to memory and learning. While the role of neuroplasticity in cognitive function is very well established, the relationship between CFC and neuroplasticity in humans remains unknown. In this study, we employed the Paired Associative Stimulation (PAS) paradigm through transcranial magnetic stimulation (TMS)-EEG study to examine the association between CFC and neuroplasticity.
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