Huang et al. published the results of a sham-controlled, randomized trial of a 10 days of 1 Hz rTMS at 90% of resting motor threshold (3 trains of 500 pulses with an inter-train interval of 10 min), applied to the right posterior parietal lobe 10–20 (P4 electrode site) in patients with generalized anxiety (GAD) [
]. They reported statistically and clinically significant and apparently lasting improvements in the active vs sham stimulation group compared with baseline for Hamilton Rating Scale for Anxiety (HRSA) scores as a primary outcome.
- Huang Z.
- Li Y.
- Bianchi M.T.
- Zhan S.
- Jiang F.
- Li N.
- Ding Y.
- Hou Y.
- Wang L.
- Ouyang Q.
- Wang Y.
Repetitive transcranial magnetic stimulation of the right parietal cortex for comorbid generalized anxiety disorder and insomnia: a randomized, double-blind, sham-controlled pilot study.
Brain Stimul. 2018; 11: 1103-1109
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- Repetitive transcranial magnetic stimulation of the right parietal cortex for comorbid generalized anxiety disorder and insomnia: a randomized, double-blind, sham-controlled pilot study.Brain Stimul. 2018; 11: 1103-1109
- Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder.Psychiatr Res. 2013; 205: 67-73
- Dynamic functional abnormalities in generalized anxiety disorders and their increased network segregation of a hyperarousal brain state modulated by insomnia.J Affect Disord. 2019; 246: 338-345
Published online: February 22, 2019
Accepted: February 11, 2019
Received: January 30, 2019
© 2019 Elsevier Inc. All rights reserved.