Interest in the modulation of slow wave activity (SWA) during non-rapid eye movement (NREM) sleep is rapidly increasing because of the important role NREM sleep plays in regulating neural plasticity and consolidating memories [
]. A growing number of studies support that transcranial electrical stimulation (tES) is able to modulate SWA, and that these changes are associated with enhanced declarative memory consolidation [
- Raven F.
- Van der Zee E.A.
- Meerlo P.
- Havekes R.
The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function.
Sleep Med Rev. 2018; 39: 3-11
]. Notably, studies utilizing tES during sleep have thus far relied on conventional sleep labs with trained sleep technicians to monitor electroencephalographic (EEG) activity and accurately time activation of tES during specific sleep stages. An automated, at-home closed-loop tES system could accelerate sleep-based tES research studies and would enable longitudinal treatment trials. Here we report on our development of such a system along with preliminary feasibility testing results.
- Marshall L.
- Helgadóttir H.
- Mölle M.
- Born J.
Boosting slow oscillations during sleep potentiates memory.
Nature. 2006; 444: 610
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- The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function.Sleep Med Rev. 2018; 39: 3-11
- Boosting slow oscillations during sleep potentiates memory.Nature. 2006; 444: 610
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Published online: February 20, 2019
Accepted: February 18, 2019
Received in revised form: February 15, 2019
Received: January 21, 2019
☆This research was conducted that the University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.
© 2019 Elsevier Inc. All rights reserved.