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Letter| Volume 12, ISSUE 3, P813-815, May 2019

Feasibility of home-based automated transcranial electrical stimulation during slow wave sleep

Published:February 20, 2019DOI:https://doi.org/10.1016/j.brs.2019.02.014
      Interest in the modulation of slow wave activity (SWA) during non-rapid eye movement (NREM) sleep is rapidly increasing because of the important role NREM sleep plays in regulating neural plasticity and consolidating memories [
      • Raven F.
      • Van der Zee E.A.
      • Meerlo P.
      • Havekes R.
      The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function.
      ]. A growing number of studies support that transcranial electrical stimulation (tES) is able to modulate SWA, and that these changes are associated with enhanced declarative memory consolidation [
      • Marshall L.
      • Helgadóttir H.
      • Mölle M.
      • Born J.
      Boosting slow oscillations during sleep potentiates memory.
      ]. Notably, studies utilizing tES during sleep have thus far relied on conventional sleep labs with trained sleep technicians to monitor electroencephalographic (EEG) activity and accurately time activation of tES during specific sleep stages. An automated, at-home closed-loop tES system could accelerate sleep-based tES research studies and would enable longitudinal treatment trials. Here we report on our development of such a system along with preliminary feasibility testing results.
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