In their recently published manuscript, “Chronic brain stimulation rewarding experience
ameliorates depression-induced cognitive deficits and restores aberrant plasticity
in the prefrontal cortex,” [
[1]
] Chakraborty and colleagues describe subjecting rats to the forced swim test (FST),
which involves dropping them into inescapable tanks of water and measuring how long
they attempt to climb and swim before becoming relatively immobile, making only the
motions necessary to keep their noses above the water line. The authors state that
they use the FST to assess the animals' “despair” following early life injections
of clomipramine hydrochloride (CLI) and, later, intracranial self-stimulation of the
lateral hypothalamus - medial forebrain bundle (LH-MFB). From their FST results, the
authors conclude, “repeated electrical self-stimulation of LH-MFB ameliorates behavioral
despair … in neonatal CLI model of depression” [
[1]
]. They go on to say, “We speculate that brain stimulation rewarding experience could
be evolved as a potential therapeutic strategy to treat affective disorders” and,
“Our results support the hypothesis that chronic brain stimulation rewarding experience
might be evolved as a potential treatment strategy for reversal of learning deficits
in depression and associated disorders” [
[1]
]. The authors offered no discussion as to other possible interpretations of the animals’
behavior or to the scientific controversy surrounding this behavioral test.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: June 21, 2019
Accepted:
June 18,
2019
Received in revised form:
June 18,
2019
Received:
March 13,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
