Abstract
Background
Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative
disorders.
Objective/hypothesis: Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain
inhibition (CBI) for improved postural stability and speech in patients with progressive
supranuclear palsy (PSP).
Methods
We performed CBI assessments with neuronavigation before and after high frequency
cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for
the conditioning pulse and a figure-of-eight coil for the test pulse and treatments.
We collected posturography data and speech samples before and after treatment.
Results
After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural
stability and speech improved. The protocol was well tolerated, but the sham was not
consistently believable.
Conclusion
Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils
with vibrotactile sham capability are needed for larger future studies.
Keywords
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Article Info
Publication History
Published online: July 25, 2019
Accepted:
July 22,
2019
Received in revised form:
July 10,
2019
Received:
June 6,
2019
Identification
Copyright
Published by Elsevier Inc.
