Highlights
- •8 sessions of HF-rTMS over the left DLPFC was effective in weight loss and decreasing food intake in obese patients.
- •The observed weight loss in the present study was greater than our previously published findings with 4 sessions of rTMS.
- •rTMS treatment had beneficial effects on improving insulin resistance.
- •rTMS reduced cardiometabolic risks associated with obesity.
Abstract
Background
Although some studies have reported significant reductions in food cravings following
the single-session of repetitive transcranial magnetic stimulation (rTMS), there is
little research on the effects of multi-session of rTMS on food consumption and body
weight in obese subjects.
Objective
We conducted 4-week randomized, sham-controlled, single-blind, parallel-group trial
to examine the effect of rTMS on body weight in obese adults.
Methods
Forty-three obese patients (body mass index [BMI] ≥25 kg/m2) aged between 18 and 70 years were randomized to the sham or real treatment group
(21 in the TMS group and 22 in the sham treatment group). A total of 8 sessions of
rTMS targeting the left dorsolateral prefrontal cortex (DLPFC) was provided over a
period of 4 weeks. The primary outcome measure was weight change in kilograms from
baseline to 4 weeks. Secondary endpoints included changes in anthropometric measures,
cardiovascular risk factors, food intake, and appetite.
Results
Participants in the rTMS group showed significantly greater weight loss from baseline
following the 8 session of rTMS (−2.75 ± 2.37 kg vs. 0.38 ± 1.0 kg, p < 0.01). Consistent with weight loss, there was a significant reduction in fat mass
and visceral adipose tissue at week 4 in the rTMS group compared with the control
group (p < 0.01). After the 8 sessions of rTMS, the TMS group consumed fewer total kilocalories
and carbohydrates per day than the control group (p < 0.05).
Conclusions
8 sessions of HF rTMS delivered to the left DLPFC were effective in inducing weight
loss and decreasing food intake in obese patients.
Trial registration
Clinical trial registered with the Clinical Trials Registry at http://cris.cdc.go.kr (KCT0002548).
Keywords
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Article info
Publication history
Published online: July 25, 2019
Accepted:
July 23,
2019
Received in revised form:
July 14,
2019
Received:
October 23,
2018
Identification
Copyright
© 2019 Published by Elsevier Inc.
