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Super refractory status epilepticus in Lafora disease interrupted by vagus nerve stimulation: A case report

Published:August 20, 2019DOI:https://doi.org/10.1016/j.brs.2019.08.008
      Refractory and super refractory status epilepticus (RSE/SRSE) require effective action to avoid death or serious and irreversible consequences on neurological functions. Regrettably, there is a considerable lack of evidence on the optimal treatment strategy [
      • Shorvon S.
      • Ferlisi M.
      The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol.
      ]. Vagus nerve stimulation (VNS), an approved chronic therapy for pharmacoresistant epilepsy, was initiated acutely in less than 40 reported patients with RSE/SRSE, interrupting 74% of cases [
      • Dibué-Adjei M.
      • Brigo F.
      • Yamamoto T.
      • Vonck K.
      • Trinka E.
      Vagus nerve stimulation in refractory and super-refractory status epilepticus - a systematic review.
      ]. However, several studies failed to provide adequate information on patient clinical characteristics, concomitant and previous treatments, stimulation protocols and data on long-term prognosis [
      • Dibué-Adjei M.
      • Brigo F.
      • Yamamoto T.
      • Vonck K.
      • Trinka E.
      Vagus nerve stimulation in refractory and super-refractory status epilepticus - a systematic review.
      ].

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