Refractory and super refractory status epilepticus (RSE/SRSE) require effective action
to avoid death or serious and irreversible consequences on neurological functions.
Regrettably, there is a considerable lack of evidence on the optimal treatment strategy
[
[1]
]. Vagus nerve stimulation (VNS), an approved chronic therapy for pharmacoresistant
epilepsy, was initiated acutely in less than 40 reported patients with RSE/SRSE, interrupting
74% of cases [
[2]
]. However, several studies failed to provide adequate information on patient clinical
characteristics, concomitant and previous treatments, stimulation protocols and data
on long-term prognosis [
[2]
].Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Brain Stimulation: Basic, Translational, and Clinical Research in NeuromodulationAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol.Brain. 2011 Oct; 134: 2802-2818https://doi.org/10.1093/brain/awr215
- Vagus nerve stimulation in refractory and super-refractory status epilepticus - a systematic review.Brain Stimul. 2019 May 14; (pii: S1935-861X): 30218-30219https://doi.org/10.1016/j.brs.2019.05.011
- Treatment with metformin in twelve patients with Lafora disease.Orphanet J Rare Dis. 2019 Jun 21; 14: 149https://doi.org/10.1186/s13023-019-1132-3
- Vagus nerve stimulation in Lafora body disease.Epilepsy Behav Case Rep. 2013 Sep 27; 1: 150-152
- Managing Lafora body disease with vagal nerve stimulation.Epileptic Disord. 2017 Mar 1; 19: 82-86https://doi.org/10.1684/epd.2017.0892
- Comparison of the effectiveness of four antiepileptic drugs in the treatment of status epilepticus according to four different efficacy criteria.Epilepsy Behav. 2015 Aug; 49: 351-353https://doi.org/10.1016/j.yebeh.2015.04.038
Article Info
Publication History
Published online: August 20, 2019
Accepted:
August 15,
2019
Received:
July 29,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
