Abstract| Volume 16, ISSUE 1, P118, January 2023

Neuromodulation of memory network in patients with Alzheimer’s disease

      Symposium title: Strengths and weaknesses of intracranial electrical stimulation in localizing functions and treating dysfunctions in the human brain
      Symposium description: Some of the most distinguished leaders in the field will present an overview of how the human brain can be studied with intracranial direct cortical stimulation and how neuropsychiatric disorders can be treated with this approach. They will discuss promises and weaknesses of this approach and suggest future directions.
      Alzheimer's disease (AD) is characterized by a profound disruption of cortical networks subserving memory and cognitive function. In an ongoing clinical trial, deep brain stimulation (DBS) of the fornix is being examined to modulate these networks to improve their function. In addition, emerging evidence from animal models and patients suggests that electrical stimulation of these circuits can restore metabolic function, improve cognition, and have reparative and regenerative effects. An update on the state of DBS approaches to treat circuit dysfunction in AD will be presented, along with a discussion of lessons learned.
      Research Category and Technology and Methods
      Clinical Research: 1. Deep Brain Stimulation (DBS)
      Keywords: DBS, Intracranial, Direct Cortical Stimulation