Abstract| Volume 16, ISSUE 1, P118, January 2023

Neuromodulation of emotion networks in patients with depression: Lessons learned

      It is now almost 20 years since the first case of subcallosal cingulate deep brain stimulation (SCC DBS) for treatment-resistant depression (TRD). Ongoing research using small experimental cohorts has continued to progress, with the implementation of refined techniques for surgical targeting and emerging clues as to which patients are most likely to benefit. Close clinical monitoring and systematic long-term follow-up have provided additional perspectives on the time course, trajectory, and long-term sustainability of DBS-mediated effects. Acute and chronic monitoring using next-generation stim/sense DBS systems has further characterized this chronology at the neural level, demonstrating distinct early and late physiological changes that suggest network plasticity and remodeling maintain the observed long-term clinical effects. Physiological measures are now combined with computer vision, and machine learning approaches to detect more subtle changes in core depression features relevant to DBS optimization. Together these experimental approaches provide a unique opportunity to link first-person experiences to changes in brain state toward a more comprehensive understanding of illness and recovery.
      Research Category and Technology and Methods
      Clinical Research: 1. Deep Brain Stimulation (DBS)