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Preventing misestimation of transcranial magnetic stimulation motor threshold with MTAT 2.0

  • Lari M. Koponen
    Affiliations
    Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
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  • Angel V. Peterchev
    Correspondence
    Corresponding author.
    Affiliations
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA
    Department of Neurosurgery, Duke University, Durham, NC, USA
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Open AccessPublished:August 05, 2022DOI:https://doi.org/10.1016/j.brs.2022.07.057
      We discovered situations in which the popular transcranial magnetic stimulation (TMS) motor threshold (MT) assessment software tool MTAT 2.0 [
      • Awiszus F.
      • Borckardt J.J.
      TMS motor threshold assessment tool (MTAT 2.0).
      ] can produce a large misestimation of the MT. We describe the issue, study it computationally, and suggest ways to address it.
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      References

        • Awiszus F.
        • Borckardt J.J.
        TMS motor threshold assessment tool (MTAT 2.0).
        2011
        • Awiszus F.
        TMS and threshold hunting.
        in: Paulus W. Tergau F. Nitsche M.A. Rothwell J.G. Ziemann U. Hallett M. Transcranial Magn. Stimul. Transcranial Direct Curr. Stimul. Elsevier, 2003: 13-23https://doi.org/10.1016/S1567-424X(09)70205-3
        • Awiszus F.
        Fast estimation of transcranial magnetic stimulation motor threshold: is it safe?.
        Brain Stimul. 2011; 4: 58-59https://doi.org/10.1016/j.brs.2010.09.004
        • Julkunen P.
        Mobile application for adaptive threshold hunting in transcranial magnetic stimulation.
        IEEE Trans Neural Syst Rehabil Eng. 2019; 27: 1504-1510https://doi.org/10.1109/TNSRE.2019.2925904
        • Tranulis C.
        • Guéguen B.
        • Pham-Scottez A.
        • Vacheron M.N.
        • Cabelguen G.
        • Costantini A.
        • et al.
        Motor threshold in transcranial magnetic stimulation: comparison of three estimation methods.
        Clin Neurophysiol. 2006; 36: 1-7https://doi.org/10.1016/j.neucli.2006.01.005
        • Goetz S.M.
        • Alavi S.M.M.
        • Deng Z.-D.
        • Peterchev A.V.
        Statistical model of motor-evoked potentials.
        IEEE Trans Neural Syst Rehabil Eng. 2019; 27: 1539-1545https://doi.org/10.1109/TNSRE.2019.2926543
        • Awiszus F.
        On relative frequency estimation of transcranial magnetic stimulation motor threshold.
        Clin Neurophysiol. 2012; 123: 2319-2320https://doi.org/10.1016/j.clinph.2012.04.014
        • Kallioniemi E.
        • Awiszus F.
        • Pitkänen M.
        • Julkunen P.
        Fast acquisition of resting motor threshold with a stimulus–response curve – possibility or hazard for transcranial magnetic stimulation applications?.
        Clin Neurophysiol Pract. 2022; 7: 7-15https://doi.org/10.1016/j.cnp.2021.10.005
        • Julkunen P.
        • Säisänen L.
        • Danner N.
        • Niskanen E.
        • Hukkanen T.
        • Mervaala E.
        • et al.
        Comparison of navigated and non-navigated transcranial magnetic stimulation for motor cortex mapping, motor threshold and motor evoked potentials.
        Neuroimage. 2009; 44: 790-795https://doi.org/10.1016/j.neuroimage.2008.09.040