Chronic posthypoxic myoclonus, or Lance-Adams syndrome (LAS), is a severely disabling
consequence of anoxia [
[1]
]. The leading symptoms of LAS are multifocal or sometimes generalized action/intention
myoclonic jerks. LAS occurs days or weeks after a brain hypoxic event from various
cardiac and/or respiratory origins. Its treatment relies on antiseizure medications
(ASM) but without a clear efficacy. We report the striking features of a patient with
LAS, refractory to many ASM, who presented generalized seizures leading to transient
decrease of myoclonus. This patient benefited from repeated electroconvulsive therapy
(ECT) to reproduce generalized seizures and to decrease her myoclonus, with a functional
testing follow-up using the Unified Myoclonus Rating Scale (UMRS) [
[2]
]. A written consent was signed by the patient for publication of her data.Keywords
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References
- Post-hypoxic myoclonus: current concepts, neurophysiology, and treatment.Tremor Other Hyperkinet Mov. 2016; 6: 409https://doi.org/10.7916/D89C6XM4
- The unified myoclonus rating Scale.Adv Neurol. 2002; 89: 361-376
- Electroconvulsive therapy in depression : current practice and future direction.Psychiatr Clin. 2018; 41: 341-353https://doi.org/10.1016/j.psc.2018.04.001
- Commentary and update on the contribution of the GABA hypothesis to understanding the mechanism of action of electroconvulsive therapy.J ECT. 2021; 37: 4-9https://doi.org/10.1097/YCT.0000000000000711
- Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors.Nat Rev Neurosci. 2005; 6: 215-229https://doi.org/10.1038/nrn1625
- The syndrome of intention or action myoclonus as a sequel to hypoxic encephalopathy.Brain. 1963; 86: 111-136https://doi.org/10.1093/brain/86.1.111
- Physiology of human posthypoxic myoclonus.Mov Disord. 2000; 15: 8-13https://doi.org/10.1002/mds.870150703
- To jerk or not to jerk: a clinical pathophysiology of myoclonus.Rev Neurol (Paris). 2016; 172 (10.106/j.neurol.2016.07.013): 465-476
- Myoclonus.in: Gilman Sid Neurobiology of disease. Academic Press, 2007: 305-317https://doi.org/10.1016/B978-012088592-3/50032-3
- Treatment of super-refractory status epilepticus.Curr Neurol Neurosci Rep. 2015; 15: 66https://doi.org/10.1007/s11910-015-0589-2
Article info
Publication history
Published online: March 17, 2023
Accepted:
March 8,
2023
Received in revised form:
February 13,
2023
Received:
January 20,
2023
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© 2023 The Authors. Published by Elsevier Inc.
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