Chronic posthypoxic myoclonus, or Lance-Adams syndrome (LAS), is a severely disabling consequence of anoxia [
]. The leading symptoms of LAS are multifocal or sometimes generalized action/intention myoclonic jerks. LAS occurs days or weeks after a brain hypoxic event from various cardiac and/or respiratory origins. Its treatment relies on antiseizure medications (ASM) but without a clear efficacy. We report the striking features of a patient with LAS, refractory to many ASM, who presented generalized seizures leading to transient decrease of myoclonus. This patient benefited from repeated electroconvulsive therapy (ECT) to reproduce generalized seizures and to decrease her myoclonus, with a functional testing follow-up using the Unified Myoclonus Rating Scale (UMRS) [
- Gupta H.V.
- Caviness J.N.
Post-hypoxic myoclonus: current concepts, neurophysiology, and treatment.
Tremor Other Hyperkinet Mov. 2016; 6: 409https://doi.org/10.7916/D89C6XM4
]. A written consent was signed by the patient for publication of her data.
- Frucht S.J.
- Leurgans S.U.
- Hallett M.
- Fahn S.
The unified myoclonus rating Scale.
Adv Neurol. 2002; 89: 361-376
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- Post-hypoxic myoclonus: current concepts, neurophysiology, and treatment.Tremor Other Hyperkinet Mov. 2016; 6: 409https://doi.org/10.7916/D89C6XM4
- The unified myoclonus rating Scale.Adv Neurol. 2002; 89: 361-376
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Published online: March 17, 2023
Accepted: March 8, 2023
Received in revised form: February 13, 2023
Received: January 20, 2023
© 2023 The Authors. Published by Elsevier Inc.
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