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Prefrontal delta oscillations during deep brain stimulation predict treatment success in patients with obsessive-compulsive disorder
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a promising neurotherapeutic approach for severe and refractory cases of obsessive-compulsive disorder (OCD). Successful VC/VS-DBS treatment alters function in frontostriatal pathways important for the etiopathogenesis of OCD [1–3]. Monitoring changes in frontostriatal functioning resulting from active DBS can reveal signatures of DBS engagement with disease-relevant pathways [1,4]. In particular, modulation of the dorsal-medial prefrontal cortex (dmPFC) seems to be crucial for therapeutic success: symptomatic OCD patients demonstrate hyperconnectivity between the VC/VS and dmPFC, which is normalized following successful VC/VS-DBS [1,5,6].
