Adaptive current tDCS up to 4 mAHigher tDCS current may putatively enhance efficacy, with tolerability the perceived limiting factor.
Effects of 6-month at-home transcranial direct current stimulation on cognition and cerebral glucose metabolism in Alzheimer's diseaseAlthough single or multiple sessions of transcranial direct current stimulation (tDCS) on the prefrontal cortex over a few weeks improved cognition in patients with Alzheimer's disease (AD), effects of repeated tDCS over longer period and underlying neural correlates remain to be elucidated.
Sham tDCS: A hidden source of variability? Reflections for further blinded, controlled trialsTranscranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique increasingly used to modulate neural activity in the living brain. In order to establish the neurophysiological, cognitive or clinical effects of tDCS, most studies compare the effects of active tDCS to those observed with a sham tDCS intervention. In most cases, sham tDCS consists in delivering an active stimulation for a few seconds to mimic the sensations observed with active tDCS and keep participants blind to the intervention.
Dry tDCS: Tolerability of a novel multilayer hydrogel composite non-adhesive electrode for transcranial direct current stimulationThe adoption of transcranial Direct Current Stimulation (tDCS) is encouraged by portability and ease-of-use. However, the preparation of tDCS electrodes remains the most cumbersome and error-prone step. Here, we validate the performance of the first “dry” electrodes for tDCS. A “dry electrode” excludes 1) any saline or other electrolytes, that are prone to spread and leaving a residue; 2) any adhesive at the skin interface; or 3) any electrode preparation steps except the connection to the stimulator.
Brain stimulation patterns emulating endogenous thalamocortical input to parvalbumin-expressing interneurons reduce nociception in miceThe bursting pattern of thalamocortical (TC) pathway dampens nociception. Whether brain stimulation mimicking endogenous patterns can engage similar sensory gating processes in the cortex and reduce nociceptive behaviors remains uninvestigated.
Tolerability and blinding of 4x1 high-definition transcranial direct current stimulation (HD-tDCS) at two and three milliampsTranscranial direct current stimulation (tDCS) is an in-demand form of neuromodulation generally regarded as safe and well tolerated. However, few studies have examined the safety, tolerability, or blinding of High Definition (HD-) tDCS, especially in older adults and at stimulation intensities of 2 milliamps (mA) or greater.
Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivoTranscranial direct current stimulation (tDCS) is a promising brain modulation technique for several disease conditions. With this technique, some portion of the current penetrates through the scalp to the cortex and modulates cortical excitability, but a recent human cadaver study questions the amount. This insufficient intracerebral penetration of currents may partially explain the inconsistent and mixed results in tDCS studies to date. Experimental validation of a transcranial alternating current stimulation-generated electric field (EF) in vivo has been performed on the cortical (using electrocorticography, ECoG, electrodes), subcortical (using stereo electroencephalography, SEEG, electrodes) and deeper thalamic/subthalamic levels (using DBS electrodes).
Direct Current Stimulation Alters Neuronal Input/Output FunctionTranscranial direct current stimulation (tDCS) is actively investigated as a tool for non-invasive brain stimulation. Across diverse applications, the general goal is to modulate neuronal excitability. tDCS produces current flow across the brain from anode to cathode. Classical in vivo animal studies demonstrate an increase in neuronal activity (firing rate) in brain regions under the anode and a decrease in activity under the cathode [1–5]. These early results motivated neurophysiological experiments with tDCS in humans  and clinical trials  with largely similar conclusions on neuronal excitability.
High-Definition and Non-invasive Brain Modulation of Pain and Motor Dysfunction in Chronic TMDTemporomandibular disorders (TMD) have a high prevalence and in many patients pain and masticatory dysfunction persist despite a range of treatments. Non-invasive brain neuromodulatory methods, namely transcranial direct current stimulation (tDCS), can provide relatively long-lasting pain relief in chronic pain patients.
The Pursuit of DLPFC: Non-neuronavigated Methods to Target the Left Dorsolateral Pre-frontal Cortex With Symmetric Bicephalic Transcranial Direct Current Stimulation (tDCS)The dose of transcranial direct current stimulation (tDCS) is defined by electrode montage and current, while the resulting brain current flow is more complex and varies across individuals. The left dorsolateral pre-frontal cortex (lDLPFC) is a common target in neuropsychology and neuropsychiatry applications, with varied approaches used to experimentally position electrodes on subjects.
Transcranial Direct Current Stimulation Accelerates Allocentric Target DetectionPrevious research on hemispatial neglect has provided evidence for dissociable mechanisms for egocentric and allocentric processing. Although a few studies have examined whether tDCS to posterior parietal cortex can be beneficial for attentional processing in neurologically intact individuals, none have examined the potential effect of tDCS on allocentric and/or egocentric processing.