Multimedia Library
Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: A phase 1 pilot trial
Several different surgical procedures targeting the limbic circuit have been utilized for severe, treatment resistant obsessive-compulsive disorder; however, there has only been limited exploration of the inferior thalamic peduncle (ITP). The aim of this study was to determine the safety and initial efficacy of ITP deep brain stimulation (DBS) in patients with severe obsessive-compulsive disorder.Long-term results after deep brain stimulation of nucleus accumbens and the anterior limb of the internal capsule for preventing heroin relapse: An open-label pilot study
Deep brain stimulation (DBS) is currently used to treat addiction, with the nucleus accumbens (NAc) as one promising target. The anterior limb of the internal capsule (ALIC) is also a potential target, as it carries fiber tracts connecting the mesocorticolimbic circuits that are crucially involved in several psychiatric disorders, including addiction. Stimulating the NAc and ALIC simultaneously may have a synergistic effect against addiction.Stimulation-induced reversed plus-minus syndrome: Insights into eyelid physiology
Pedunculopontine nucleus (PPN) defines a group of neurons sparsely distributed within the reticular formation of brainstem tegmentum thought to be part of the mesencephalic locomotor region [1]. Deep brain stimulation (DBS) of PPN is an experimental treatment for axial symptoms of Parkinson disease with mixed results [1].Chronic deep brain stimulation in an Alzheimer's disease mouse model enhances memory and reduces pathological hallmarks
Alzheimer's disease (AD) is a progressive degenerative disorder that currently remains extremely disabling. Recent work has shown that deep brain stimulation (DBS) has promising effects in AD patients. In parallel to the clinical trials, we investigated the impact of chronic DBS in 3xTg mice, a well-established animal model of AD.Systematic review of hardware-related complications of Deep Brain Stimulation: Do new indications pose an increased risk?
Deep Brain Stimulation (DBS) is an effective treatment extended broadly to many neurological and psychiatric disorders. Nevertheless, complications may arise during DBS procedures or following implantation due to implanted hardware. This may result in both minor and major adverse events that may necessitate hardware removal and/or compromise maximal therapeutic benefit for the patient.Two indications, one target: Concomitant epilepsy and Tourettism treated with Centromedian/parafascicular thalamic stimulation
The Centromedian/parafascicular (CM/Pf) thalamic nuclear complex is a deep brain stimulation (DBS) target for medically refractory Tourette syndrome (TS) as well as for patients affected by resistant generalized tonic-clonic (GTC) seizures [1–3].Deep Brain Stimulation Modulates Gamma Oscillations and Theta–Gamma Coupling in Treatment Resistant Depression
Deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG) is becoming an effective therapeutic option for treatment resistant depression (TRD).Subcallosal Cingulate Connectivity in Anorexia Nervosa Patients Differs From Healthy Controls: A Multi-tensor Tractography Study
Anorexia nervosa is characterized by extreme low body weight and alterations in affective processing. The subcallosal cingulate regulates affect through wide-spread white matter connections and is implicated in the pathophysiology of anorexia nervosa.Subdural Continuous Theta Burst Stimulation of the Motor Cortex in Essential Tremor
Continuous theta-burst stimulation (cTBS) using short bursts of low-intensity, high-frequency (50 Hz), pulses repeated every 200 ms is a repetitive transcranial magnetic stimulation (rTMS) protocol with inhibitory effects on human cortex [1]. Several studies suggested a role for the primary motor cortex (M1) within the central oscillatory network generating Essential Tremor (ET) [2]. Accordingly, recent studies have demonstrated that cTBS over M1 leads to a small and transient reduction of the tremor amplitude in ET patients [3,4].Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease
Deep Brain Stimulation (DBS) is thought to improve the symptoms of selected neurological disorders by modulating activity within dysfunctional brain circuits. To date, there is no evidence that DBS counteracts progressive neurodegeneration in any particular disorder.
