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Prefrontal delta oscillations during deep brain stimulation predict treatment success in patients with obsessive-compulsive disorder
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a promising neurotherapeutic approach for severe and refractory cases of obsessive-compulsive disorder (OCD). Successful VC/VS-DBS treatment alters function in frontostriatal pathways important for the etiopathogenesis of OCD [1–3]. Monitoring changes in frontostriatal functioning resulting from active DBS can reveal signatures of DBS engagement with disease-relevant pathways [1,4]. In particular, modulation of the dorsal-medial prefrontal cortex (dmPFC) seems to be crucial for therapeutic success: symptomatic OCD patients demonstrate hyperconnectivity between the VC/VS and dmPFC, which is normalized following successful VC/VS-DBS [1,5,6].Decoding voluntary movements and postural tremor based on thalamic LFPs as a basis for closed-loop stimulation for essential tremor
High frequency Deep brain stimulation (DBS) targeting motor thalamus is an effective therapy for essential tremor (ET). However, conventional continuous stimulation may deliver unnecessary current to the brain since tremor mainly affects voluntary movements and sustained postures in ET.Non-motor outcomes of subthalamic stimulation in Parkinson's disease depend on location of active contacts
Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and non-motor symptoms (NMS) in Parkinson's disease (PD). Few studies have investigated the influence of the location of neurostimulation on NMS.Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease
Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and non-motor symptoms (NMS) in advanced Parkinson's disease (PD). However, considerable inter-individual variability has been observed for QoL outcome.Beneficial Effects of Bilateral Subthalamic Stimulation on Non-Motor Symptoms in Parkinson's Disease
Subthalamic nucleus (STN) deep brain stimulation (DBS) is well established for the symptomatic treatment of Parkinson's disease (PD) improving motor symptoms, activities of daily living (ADL), and quality of life (QoL) [1–3]. Non-motor symptoms (NMS) play a crucial role for QoL in patients with PD [4,5]. Long-term effects of DBS on neuropsychological [6,7] and neuropsychiatric symptoms [8,9] have been studied. However, these symptoms contribute only to a part of NMS in patients with PD. Previously published studies on a wider range of NMS have methodological limitations due to a lack of objective clinician-based [10], patient-based [11,12] or any validated assessment at all [12], and small cohort sizes of only 10 [13,14] or 11 subjects followed up on 6 month [12].
