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Effects of 6-month at-home transcranial direct current stimulation on cognition and cerebral glucose metabolism in Alzheimer's disease
Although single or multiple sessions of transcranial direct current stimulation (tDCS) on the prefrontal cortex over a few weeks improved cognition in patients with Alzheimer's disease (AD), effects of repeated tDCS over longer period and underlying neural correlates remain to be elucidated.High intensity aerobic exercise does not prime the brain for anodal transcranial direct current stimulation
The benefits of both regular and acute exercise on cognitive function are well-established. One candidate mechanism is the increase in brain derived neurotropic factor (BDNF), which is involved in exercise-induced neuroplasticity [1]. An increase in serum BDNF after a single exercise session may create favourable conditions for adaptive plasticity [2], and has also been shown to influence anodal transcranial direct current stimulation (a-tDCS) in mice [3]. We investigated the acute effects of a single bout of high-intensity interval training (HIIT) performed prior to dorsolateral pre-frontal cortex (DLPFC) a-tDCS on cognitive performance, serum BDNF, and the cerebral haemodynamic response in healthy adults.Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice
The vagus nerve is involved in regulating immunity and resolving inflammation. Current strategies aimed at modulating neuroinflammation and cognitive decline, in many cases, are limited and ineffective.Deep brain stimulation to the medial forebrain bundle for depression- long-term outcomes and a novel data analysis strategy
Deep brain stimulation (DBS) of the supero-lateral branch of the medial forebrain bundle (slMFB) in treatment-resistant depression (TRD) is associated with acute antidepressant effects.Stimulating cognition in schizophrenia: A controlled pilot study of the effects of prefrontal transcranial direct current stimulation upon memory and learning
Schizophrenia is characterized by prominent cognitive deficits, impacting on memory and learning; these are strongly associated with the prefrontal cortex.Older Adults Improve on Everyday Tasks after Working Memory Training and Neurostimulation
Anyone struggling to straighten age-stiffened knees can attest to the physical consequences of aging. More distressing are cognitive changes, especially those related to executive functions (EF) such as problem solving, decision-making, working memory (WM), and planning [1]. These higher functions are needed to complete everyday activities and to maintain independence with age. Neurally, EF tasks rely on frontal lobe structures that are particularly susceptible to age-related gray matter volume loss and reduced functional connectivity [2–4].A Systematic Review and Meta-Analysis of the Effects of Transcranial Direct Current Stimulation (tDCS) Over the Dorsolateral Prefrontal Cortex in Healthy and Neuropsychiatric Samples: Influence of Stimulation Parameters
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation (NIBS) technique that modulates spontaneous cortical activity using a low-intensity direct current (e.g. 1–2 mA) [1]. First studies evaluated tDCS effects over the motor cortex [2,3]; although more recent research has also focused on its effects over the dorsolateral prefrontal cortex (DLPFC), particularly to treat psychiatric disorders [4] and to modulate cognitive performance [5–8]. These cognitive results can be useful to predict treatment outcome.Effects of Anodal Transcranial Direct Current Stimulation on Working Memory: A Systematic Review and Meta-Analysis of Findings From Healthy and Neuropsychiatric Populations
Cognitive deficits, including working memory (WM) impairment, are core features of a number of neuropsychiatric disorders, contributing substantially to burden of disease and remaining largely refractory to conventional drug-based therapies [1–3]. Transcranial direct current stimulation (tDCS) is emerging as a safe and relatively inexpensive means of modulating both psychological and physiological processes through the non-invasive application of low-voltage currents to the brain [4]. Indeed, a number of studies have now reported beneficial effects of tDCS on memory function in neuropsychiatric populations [5–12] as well as in healthy individuals [13–24].
